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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Diabetes is an Independent Risk Factor for Stroke Recurrence in Stroke Patients: A Meta-analysis
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Diabetes is an Independent Risk Factor for Stroke Recurrence in Stroke Patients: A Meta-analysis

机译：糖尿病是中风患者中风复发的独立危险因素：Meta分析

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Background: This study aimed to assess the association between diabetes and risk of stroke recurrence (especially ischemic stroke recurrence) and to evaluate whether diabetes was an independent predictor for stroke recurrence in stroke patients with diabetes. Methods: The relevant studies were identified through searching databases of PubMed, EMBASE, and Cochrane library. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled to evaluate the association between diabetes and risk of stroke recurrence. Funnel plot and Egger's regression tests were used to assess publication bias. All statistical analyses were conducted in Stata 12.0. Results: Eighteen studies containing totally 43,899 participants were included in the meta-analysis. The results showed that stroke recurrence risk of all stroke patients with diabetes was significantly higher than those without diabetes (HR, 1.45; 95% CI, 1.32-1.59), similar results were achieved in ischemic stroke patients (HR, 1.44; 95% CI, 1.28-1.61), and there were no regional differences (Europe: HR, 1.28; 95% CI, 1.13-1.44; USA: HR, 1.89; 95% CI, 1.53-2.33; Asia: HR, 1.57, 95% CI, 1.28-1.92, respectively) and age differences (mean age,70 years: HR, 1.58; 95% CI, 1.34-1.86; mean age >= 70 years: HR, 1.27; 95% CI, 1.11-1.45, respectively). The heterogeneity of all included studies was not statistically significant, and no publication bias was observed. Conclusions: This meta-analysis shows that diabetes is an independent risk factor for stroke recurrence in stroke patients. (C) 2015 Published by Elsevier Inc. on behalf of National Stroke Association
机译：背景：本研究旨在评估糖尿病与中风复发（特别是缺血性卒中复发）之间的关联，并评估糖尿病是否是患有糖尿病患者中风复发的独立预测因子。方法：通过搜索PubMed，Embase和Cochrane图书馆的数据库来确定相关研究。合并调整后的危险比（HRS）和95％的置信区间（CIs）以评估糖尿病与中风复发风险之间的关联。漏斗情节和Egger的回归测试用于评估出版物偏见。所有统计分析都在Stata 12.0中进行。结果：含有完全43,899名参与者的十八研究包括在META分析中。结果表明，所有糖尿病患者的中风复发风险明显高于患有糖尿病（HR，1.45; 95％CI，1.32-1.59）的卒中患者，在缺血性卒中患者中实现了类似的结果（HR，1.44; 95％CI ，1.28-1.61），没有区域差异（欧洲：HR，1.28; 95％CI，1.13-1.44;美国：HR，1.89; 95％CI，1.53-2.33;亚洲：HR，1.57,95％CI ，分别为1.28-1.92）和年龄差异（平均年龄，70年：HR，1.58; 95％CI，1.34-1.86;平均年龄> = 70年：HR，分别为1.27; 95％CI，1.11-1.45分别为1.11-1.45） 。所有包括研究的异质性在统计学上没有统计学意义，并且没有观察到出版物偏差。结论：这种荟萃分析表明，糖尿病是中风患者中风复发的独立危险因素。 （c）2015年由elsevier公司发布代表国家冲程协会

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