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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Effect of beta-Adrenergic Antagonists on In-Hospital Mortality after Ischemic Stroke
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Effect of beta-Adrenergic Antagonists on In-Hospital Mortality after Ischemic Stroke

机译：β-肾上腺素能拮抗剂对缺血性卒中后住院死亡率的影响

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Background: Ischemic stroke accounts for 85%-90% of all strokes and currently has very limited therapeutic options. Recent studies of beta-adrenergic antagonists suggest they may have neuroprotective effects that lead to improved functional outcomes in rodent models of ischemic stroke; however, there are limited data in patients. We aimed to determine whether there was an improvement in mortality rates among patients who were taking beta-blockers during the acute phase of their ischemic stroke. Methods: A retrospective analysis of a prospectively collected database of ischemic stroke patients was performed. Patients who were on beta-adrenergic antagonists both at home and during the first 3 days of hospitalization were compared with patients who were not on beta-adrenergic antagonists to determine the association with patient mortality rates. Results: The study included a patient population of 2804 patients. In univariate analysis, use of beta-adrenergic antagonists was associated with older age, atrial fibrillation, hypertension, and more-severe initial stroke presentation. Despite this, multivariable analysis revealed a reduction in in-hospital mortality among patients who were treated with beta-adrenergic antagonists (odds ratio, .657; 95% confidence interval, .655-.658). Conclusions: The continuation of home beta-adrenergic antagonist medication during the first 3 days of hospitalization after an ischemic stroke is associated with a decrease in patient mortality. This supports the work done in rodent models suggesting neuroprotective effects of beta-blockers after ischemic stroke. (C) 2015 by National Stroke Association
机译：背景：缺血性卒中占所有笔触的85％-90％，目前具有非常有限的治疗选择。最近对β-肾上腺素能拮抗剂的研究表明它们可能具有神经保护作用，导致缺血性卒中啮齿动物模型中的功能性结果改善;但是，患者数据有限。我们旨在确定在缺血性卒中急性期内服用β阻滞剂的患者是否存在改善。方法：进行对缺血性脑卒中患者的前瞻性收集数据库的回顾性分析。与未在β-肾上腺素能拮抗剂的患者进行比较，患有β-肾上腺素能拮抗剂的患者，以确定与患者死亡率的关系。结果：该研究包括2804名患者的患者人口。在单变量分析中，使用β-肾上腺素能拮抗剂与年龄较大，心房颤动，高血压和更严重的初始中风呈现有关。尽管如此，多变量的分析表明，用β-肾上腺素能拮抗剂治疗的患者的住院死亡率降低（赔率比，.657; 95％置信区间，.655-.658）。结论：在缺血性中风后，在住院后的前3天内延续家庭β-肾上腺素能拮抗剂药物与患者死亡率降低有关。这支持啮齿动物模型中所做的工作，表明缺血性卒中后β-阻滞剂的神经保护作用。 （c）2015年国家冲程协会

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