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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Plasma Brain Natriuretic Peptide is a Marker of Prognostic Functional Outcome in Non-Cardioembolic Infarction
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Plasma Brain Natriuretic Peptide is a Marker of Prognostic Functional Outcome in Non-Cardioembolic Infarction

机译：血浆脑利钠肽是非心脏栓塞梗死预后功能结果的标志物

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Background: High plasma levels of brain natriuretic peptide (BNP) may also be observed in patients with non-cardioembolic infarction (CEI). We aimed to evaluate the relation between plasma BNP level, clinical parameters, and functional outcome in patients with and without CEI. Method: This study analyzed consecutive Japanese patients with acute ischemic stroke. Correlations between plasma BNP level and conventional risk factors for ischemic stroke were examined. Values of P less than .05 were considered statistically significant. Results: This study analyzed 718 acute ischemic stroke patients (445 men and 273 women; mean age, 73.9 years). Mean plasma level of BNP was significantly higher for CEI (366.6 pg/ml) than for non-CEI (105.6 pg/ml; P = 3) at hospitalization and discharge were associated with significantly higher plasma BNP level than good outcome (modified Rankin Scale score <= 2) for both CEI and non-CEI. On multiple regression analysis, log-BNP was significantly associated with female sex, smoking, triglyceride, and creatinine clearance in CEI. In non-CEI, log-BNP was significantly associated with systolic/diastolic blood pressure, triglyceride, high-density lipoprotein cholesterol, and creatinine clearance. Conclusion: Irrespective of the presence of CEI, plasma BNP offers a marker of prognostic functional outcome. We clarified the characteristics and differences associated with plasma BNP in CEI and non-CEI, and our results suggest that plasma BNP can provide a useful marker of brain damage and neurohumoral dynamics in acute ischemic stroke.
机译：背景：在非心脏栓塞梗死患者（CEI）的患者中也可以观察到高血浆水平的脑钠尿肽（BNP）。我们旨在评估血浆BNP水平，临床参数和无级联患者功能结果的关系。方法：本研究分析了急性缺血性卒中的连续日本患者。检查了血浆BNP水平与常规危险因素的相关性检查缺血性卒中。 P值小于.05被认为是统计学意义的。结果：本研究分析了718例急性缺血性卒中患者（445名男性和273名女性;平均年龄，73.9岁）。对于CEI（366.6pg / ml）而言，BNP的平均血浆水平比在住院期间的非CEI（105.6 pg / ml; p = 3）显着较高，并且在良好的结果中与血浆BNP水平显着高的血浆BNP水平（改进的Rankin规模）相关分数<= 2）对于CEI和非CEI。在多元回归分析中，Log-BNP与CEI中的女性性，吸烟，甘油三酯和肌酐清除显着相关。在非CEI中，LOG-BNP与收缩/舒张压，甘油三酯，高密度脂蛋白胆固醇和肌酐清除有显着相关。结论：无论CEI的存在如何，血浆BNP都提供了预后功能结果的标志物。我们阐明了与CEI和非CEI中血浆BNP相关的特征和差异，我们的结果表明血浆BNP可以在急性缺血性卒中中提供脑损伤和神经胃部动态的有用标志物。

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