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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Parity As a Protective Biomarker Against Silent Brain Infarction in Community-Dwelling Older Adults: The Sefuri Study
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Parity As a Protective Biomarker Against Silent Brain Infarction in Community-Dwelling Older Adults: The Sefuri Study

机译：作为一种保护生物标志物，免受社区住宅年龄较大的成年人中的沉默脑梗塞：SEFURI研究

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Background: Although several studies have reported an association between parity and increased risk of stroke, this relationship remains controversial. Aims: The present study aimed to determine whether parity is associated with silent brain infarction (SBI), independent of other confounders. Methods: We analyzed the brain magnetic resonance imaging findings in 576 of community-dwelling older adults with a mean age of 72.1 years. All female participants were asked to provide information regarding the total number of live births, their age at the last parity, and their age at menopause. Results: The prevalence of SBI and the number of infarcts per participant were higher in men than in women. Although all women who had given birth (0, 1-2, 3-4, or 5+ times) exhibited lower age-adjusted odds ratios (ORs) for SBI than men, a significant difference was observed between women with = 5 births and men after adjustment for common vascular risk factors (OR: .348, 95% confidence interval [95% CI]: .123-.986). Among women who had given birth, the relationship between fertility and SBI was attenuated, but was enhanced after adjustment for age at the last parity (OR: .300, 95% CI: .102-.886). Conclusions: Our findings indicate that fertile women may be protected against SBI or cerebral small vessel disease via the biological effects associated with reproductive activity, and that high fertility may be a marker of protection against SBI. However, late childbearing may blunt protective effects of fertility against SBI.
机译：背景：虽然有几项研究报告了平等之间的关联和中风的风险增加，但这种关系仍然存在争议。目的：本研究旨在确定奇偶校验是否与沉默脑梗塞（SBI）相关，独立于其他混乱。方法：我们分析了576年的脑磁共振成像在社区住宅的脑磁共振成像发现，平均年龄为72.1岁。要求所有女性参与者被要求提供有关休闲出生物总数的信息，他们在最后一个平等的年龄及其更年期的年龄。结果：男子患者的患病率和每位参与者的梗死数量高于女性。虽然所有给予出生（0,1-2,3-4或5次）的所有妇女都表现出较低的年龄调整后的SBI的差异（ORS）比男性在妇女之间观察到显着差异; = 5调整常见血管危险因素（或：.348,95％置信区间[95％CI]：.123-.986）后，出生和男性。在出生的妇女中，生育与SBI之间的关系衰减，但在最后一个平等（或：.300,95％CI：.102-.886）调整后调整后得到增强。结论：我们的研究结果表明，可以通过与生殖活动相关的生物学作用来保护肥沃的妇女免受SBI或脑小血管疾病，并且高生育能力可能是对SBI保护的标记。然而，迟到的生育可能会对生育能力突出对SBI的保护作用。

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