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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Association of Hyponatremia and Risk of Short- and Long-Term Mortality in Patients with Stroke: A Systematic Review and Meta-Analysis
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Association of Hyponatremia and Risk of Short- and Long-Term Mortality in Patients with Stroke: A Systematic Review and Meta-Analysis

机译：卒中患者的低钠血症关联与短期和长期死亡率的风险：系统审查和荟萃分析

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Background: Hyponatremia is the most common electrolyte disorder in the clinic practice and it is closely related to the prognosis of various diseases. Studies reported that hyponatremia increased the risk of stroke mortality while yielded inconsistent findings during the follow-up period. Thus, a systematic review and meta-analysis to assess the relationship between hyponatremia and the short-term (within 90 days) and long-term (more than 1 year) prognosis of stroke patients was conducted. Methods: A computerized systematic literature search was performed before November of 2018 for relevant articles evaluating the relationship between hyponatremia and all-cause mortality risk in stroke patients. Pooled relative risk (RR) and hazard risk (HR) with 95% confidence interval (CI) were calculated using DerSimonian-Laird random-effects model. Subgroup analyses were performed according to the follow-up period, types of stroke, different controls, sample size, and sampling time. Results: A total of 12 studies with 21,973 patients were identified. Compared to the nonhyponatremia patients, hyponatremia was associated with a higher risk of all-cause mortality in short-term (RR 1.61, 95% CI 1.33-1.96; HR 1.78 95% CI 1.19-2.75) and long-term follow-up (RR 1.77, 95% CI 1.27-2.47; HR 2.23,95% CI 1.30-3.82). Subgroups analysis showed the similar results in most subgroups. Conclusions: This meta-analysis concludes that hyponatremia has a significant prognostic value for short-and long-term prognosis to stroke patients.
机译：背景：低钠血症是临床实践中最常见的电解质障碍，与各种疾病的预后密切相关。研究报告称，低钠血症增加了行程死亡率的风险，同时在随访期间产生了不一致的结果。因此，进行了系统评估和荟萃分析，以评估低血血症和短期（在90天内）和长期（超过1年）的中风患者的预后的关系。方法：在2018年11月之前进行计算机化系统文献搜索，用于评估卒中患者的低钠血症和全导致死亡率之间关系的相关文章。使用Dersimonian-Laird随机效应模型计算汇总的相对风险（RR）和危险风险（HR），具有95％置信区间（CI）。根据随访期，行程类型，不同的控制，样本大小和采样时间进行亚组分析。结果：共鉴定了12例患者的12项研究。与非石斑血症患者相比，短期内患有较高的抗癫痫血症的风险较高（RR 1.61,95％CI 1.33-1.96; HR 1.78 95％CI 1.19-2.75）和长期随访（ RR 1.77,95％CI 1.27-2.47; HR 2.23,95％CI 1.30-3.82）。亚组分析显示了大多数亚组的结果。结论：这种荟萃分析得出结论，低钠血症对卒中患者的短期和长期预后具有显着预后价值。

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