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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Serum Aldosterone Is Associated with Cerebral Artery Atherosclerosis and Calcification
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Serum Aldosterone Is Associated with Cerebral Artery Atherosclerosis and Calcification

机译：血清醛固酮与大脑动脉动脉粥样硬化和钙化有关

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Background and Purpose: Elevated serum aldosterone concentration is known to be linked with elevated risk of cerebrovascular events as a result of vascular senescence. We studied the association between serum aldosterone concentration and cerebral arteriosclerosis status involving cerebral atherosclerosis burden and cerebral vascular calcification. Methods: A total of 207 patients (mean age = 62.40 +/- 10.54, 70 female patients) admitted with acute ischemic stroke from a single center-based stroke registry were included in the study. The participants were categorized into 4 groups in accordance to the serum aldosterone concentration. Cerebral atherosclerosis burden was derived as the stenosis degree of main intracranial arteries, and cerebral artery calcification was investigated from the cavernous portions of both internal carotid arteries from brain computed tomography angiography. Results: The median aldosterone was 146.00 pg/mL; interquartile range was 133.18-172.10 pg/mL. Advanced intracranial atherosclerosis was present in 134 patients (64.7%) and advanced intracranial arterial calcification was present in 77 patients (37.2%). The prevalence of cerebral atherosclerosis burden and cerebral artery calcification showed increasing tendency through the aldosterone quartiles. Multivariable logistic regression analysis including age, sex, vascular risk factors, estimated glomerular filtration rate and aldosterone quartiles disclosed that the highest serum aldosterone quartile was an independent predictor of advanced intracranial atherosclerosis (odds ratio, 5.07; 95% confidence interval, 1.82-14.17; P-trend = .001) and advanced intracranial arterial calcification (odds ratio, 6.24; 95% confidence interval, 2.03-19.22; P-trend = .001). Conclusions: An increased serum aldosterone concentration was independently associated with intracranial atherosclerosis burden and arterial calcification. Future studies should investigate whether aldosterone antagonists prevent stroke in at risk population.
机译：背景和目的：已知血清醛固酮浓度升高，并且由于血管衰老而导致脑血管事件的升高风险。我们研究了血清醛固酮浓度与脑动脉硬化状态之间的关联，涉及脑动脉粥样硬化负荷和脑血管钙化。方法：在研究中，共有207名患者（平均年龄= 62.40 +/-10.54,70例女性患者）征用急性缺血性卒中的急性缺血性卒中。根据血清醛固酮浓度，将参与者分为4组。脑动脉粥样硬化负担是主要的颅内动脉的狭窄程度，并从脑电相色谱血管造影的内部颈动脉的海绵体部分研究了脑动脉钙化。结果：中位数醛固酮为146.00 pg / ml;狭隘的范围是133.18-172.10 pg / ml。晚期颅内动脉粥样硬化存在于134名患者（64.7％）中，77名患者中存在晚期颅内动脉钙化（37.2％）。脑动脉粥样硬化负荷和脑动脉钙化的患病率显示通过醛固酮四分位数的趋势增加。多变量逻辑回归分析包括年龄，性别，血管危险因素，估计的肾小球过滤速率和醛固酮四分位数，即最高血清醛固酮四分位数是晚期颅内动脉粥样硬化的独立预测因子（赔率比，5.07; 95％置信区间，1.82-14.17; p-trend = .001）和晚期颅内动脉钙化（差距比例，6.24; 95％置信区间，2.03-19.22; p-trend = .001）。结论：血清醛酮浓度增加与颅内动脉粥样硬化负荷和动脉钙化独立相关。未来的研究应该调查醛固酮拮抗剂是否预防风险人群中风。

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