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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Association Between Silent Brain Infarcts and Cognitive Function: A Systematic Review and Meta-Analysis
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Association Between Silent Brain Infarcts and Cognitive Function: A Systematic Review and Meta-Analysis

机译：沉默脑梗塞与认知功能之间的关联：系统评价和荟萃分析

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Background and Purpose: Silent brain infarct (SBI), which has traditionally been considered clinically silent, has been proposed as a subclinical risk marker for future cognitive function decline. Methods: We conducted a systematic review of literature in the Cochrane Library, MEDLINE, EMBASE, and the China National Knowledge Infrastructure database. Results: In the end, 19 case-control studies, comprising 6712 participants, and 3 prospective cohort studies comprising 4433 participants, met all inclusion criteria and were included in the systematic review. Meta-analysis of 9 studies showed that SBI was an important factor in cognitive function decline (Mini-Mental State score) (standardized mean difference -.47, 95% confidence interval; -.72 to -.22). Another meta-analysis of 4 studies reported the SBI was an independent factor in cognitive dysfunction (Montreal Cognitive Assessment Scale) (standardized mean difference -3.36, 95% confidence interval; -5.90 to -.82). Ten studies further reported that SBI was associated with decreases in specific areas of cognitive function. Conclusions: These results suggest that rather than being clinically silent, SBI might be a factor inducing cognitive dysfunction.
机译：背景和目的：传统上被认为是临床沉默的无声脑梗塞（SBI）被提出作为未来认知功能下降的亚临床风险标志。方法：我们对Cochrane图书馆，Medline，Embase和中国国家知识基础设施数据库进行了系统审查。结果：最终，19个案例对照研究，包括6712名参与者，以及3名潜在队列研究，包括4433名参与者，符合所有纳入标准，并纳入系统审查。荟萃分析9研究表明，SBI是认知功能下降（迷你精神状态得分）的重要因素（标准化平均差异-47,95％置信区间; -.72至22）。 4项研究的另一个荟萃分析报告称SBI是认知功能障碍（蒙特利尔认知评估规模）的独立因素（标准化平均差-3.36,95％置信区间; -5.90至-82）。进一步研究进一步研究SBI与认知功能的特定领域的降低有关。结论：这些结果表明，而不是临床沉默，SBI可能是诱导认知功能障碍的因素。

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