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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Incidence of Convexal Subarachnoid Hemorrhage in the Elderly: The Mayo Clinic Study of Aging
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Incidence of Convexal Subarachnoid Hemorrhage in the Elderly: The Mayo Clinic Study of Aging

机译：老年人凸性蛛网膜下腔出血的发病率：老龄化的梅奥诊所研究

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Objectives: Nontraumatic convexal subarachnoid hemorrhages in the elderly can be a manifestation of cerebral amyloid angiopathy associated with a high risk of future intracerebral hemorrhage. The incidence in the elderly population is unknown. Our objectives were to: 1) determine the incidence of convexal subarachnoid hemorrhage in a population-based study, and, 2) to compare apopolipoprotein-E genotype and amyloid positron emission tomographic (PET) imaging for those with versus without hemorrhage. Methods: Between 11/29/2004 and 3/11/2017, 4462 individuals without hemorrhage at baseline participated in the populationbased Mayo Clinic Study of Aging. We used the Rochester Epidemiology Project medical records-linkage system to identify intracerebral hemorrhages. Records and images were reviewed to identify convexal subarachnoid hemorrhage. Neuroimaging characteristics, demographics, medications, and apopolipoprotein-E genotype were recorded. Results: Four cases were identified. The incidence of convexal subarachnoid hemorrhage was 14.1 per 100,000 person years. Three occurred in women, median age, 79 (range: 71-84). One patient had coexisting cerebral microbleeds. Two participants developed a subsequent lobar intracerebral hemorrhage at a median of 4.75 years after convexal subarachnoid hemorrhage. The apopolipoprotein-E -allele combinations of the 4 were: 3/3, 3/3, 2/2, and 2/3. On Pittsburgh Compound B-PET imaging, median standardized uptake value ratio with convexal subarachnoid hemorrhage was 1.86 (range: 1.38-2.34).
机译：目的：老年人的非创伤性凸性蛛网膜下腔出血可以是与未来未来脑出血的高风险相关的脑淀粉样血管病的表现。老年人口的发病率未知。我们的目标是：1）确定基于人群的研究中凸性蛛网膜下腔出血的发生率，以及2）以比较用于没有出血的那些对那些人进行的Apoghipoplotein-E基因型和淀粉样蛋白正电子发射断层（PET）成像。方法：11/29/2004和11/11/11/11/11/11/11/11/11/11/11/11/11/11/11/11/11/11/1462个体在基线中没有出血的个体参与了龄的梅奥临床研究。我们使用罗彻斯特流行病学项目医疗记录 - 联系系统来鉴定脑内出血。审查了记录和图像以鉴定凸性蛛网膜下腔出血。记录了神经影像学，人口统计学，药物和Apoghipoplotein-E基因型。结果：确定了四种病例。凸蛛网膜下腔出血的发病率为每10万人为14.1岁。三名妇女发生，中位年龄，79（范围：71-84）。一名患者还共存了脑微微肌肉。两位参与者在凸性蛛网膜下腔出血后4.75岁的中位开发了随后的洛洛颅内出血。 4的Apoghipoplotein-E-Elalline组合为：3/3,3 / 3,2 / 2和2/3。在Pittsburgh化合物B-PET成像中，与凸蛛网膜下腔出血的中值标准化摄取值为1.86（范围：1.38-2.34）。

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