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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Activated Protein C Resistance in Patients With Arterial Ischemic Stroke
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Activated Protein C Resistance in Patients With Arterial Ischemic Stroke

机译：动脉缺血性卒中患者的活性蛋白C抗性

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Background: Activated C protein resistance (APC-R) has recently been reported to be a common cause of thrombophilia; it may be acquired or caused by a genetic defect (factor V Leiden mutation). It is clear that there is an association between APC-R and venous thrombosis. It has been suggested that there is a possible relationship of APC-R with arterial ischemic stroke (IS), but case-control studies have not given enough clues for considering APC-R as a main risk factor. Objectives: To assess the incidence of APC-R in patients with IS of several ethiologies in Buenos Aires. Patients and methods: Seventy-two patients with IS were assessed for signs or symptoms of previous clinical thrombophilia and the presence of vascular risk factors (RF). They were searched for APC-R (COATEST, APC resistance-V, with a predilution of the samples) test. Determinations were carried out between 1 to 4 months after the ischemic episode. The plasma of 50 healthy control subjects (blood donors) was used as controls. Results: None of the patients had signs of previous thrombophilia; 57 (79.2%) had RF for IS, and 3 (4.2%) had APC-R (all of them with RF). One subject in the control group (2%) showed a low APC response (1/50). The ocurrence of APC-R among patients with stroke was not significantly higher when compared with the ocurrence of APC-R among the control subjects. Conclusions: In the present series, the incidence of factor V Leiden related APC-R in the group with IS was similar to the healthy population. Other risk factors were associated in patients showing APC-R.
机译：背景：最近据报道，活化的C蛋白抗性（APC-r）是血栓管粒细胞的常见原因;它可以由遗传缺陷（因子V leiden突变）获得或引起。很明显，APC-R与静脉血栓形成之间存在关联。已经提出，具有动脉缺血性卒中的APC-R的可能关系，但病例对照研究没有给予足够的线索，以考虑APC-R作为主要风险因素。目的：评估患者APC-R的发病率在Buenos Aires中的几种夫妇。患者和方法：评估七十二名患者以对先前临床血栓性血栓性的迹象或症状以及血管危险因素（RF）的存在。他们被搜索为APC-R（COATEST，APC电阻-V，以填充样品）测试。在缺血发作后1至4个月之间进行测定。将50个健康对照受试者（献血者）的血浆用作对照。结果：没有患者患有以前的血栓性迹象; 57（79.2％）具有rf，3（4.2％）具有APC-R（所有rf）。对照组中的一个受试者（2％）显示出低APC响应（1/50）。与对照受试者中APC-R的ocurrence相比，卒中患者中APC-R的opc-r的opc-r的杂志并没有显着升高。结论：本系列中，本集团中因子V leiden相关APC-R的发生率与健康人口相似。其他危险因素在显示APC-R的患者中有关。

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