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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Metabolic Profile of Sub-Saharan African Patients Presenting with First-ever-in-lifetime Stroke: Association with Insulin Resistance
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Metabolic Profile of Sub-Saharan African Patients Presenting with First-ever-in-lifetime Stroke: Association with Insulin Resistance

机译：亚撒哈拉以南非洲患者的代谢概况呈现出第一寿命中风：与胰岛素抵抗联系

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Background: To assess the pattern of metabolic profile associated with first stroke episode in a hospital setting in Cameroon. Methods: All patients admitted for first-ever-in-lifetime stroke over a 6-month period were eligible for inclusion in the study. The 84% participation rate yielded 57 of 68 patients between 16 and 85 years of age. Fifty-seven control subjects were selected to match patients included for age range, sex, and known hypertension and diabetes. We measured fasting serum glucose, insulin, and lipids in controls and in patients between days 3 and 7 after admission. Results: Total cholesterol was comparable in patients and controls (172.6 ± 39.5 v 175.4 ± 49.7 mg/dL; P = .75), as were triglycerides (129.4 ± 56.1 v 122.4 ± 60.7 mg/dL; P = .53). high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than in controls (37.4 ± 20.6 v 50.2 ± 18.0 mg/dL; P = .001), with comparable levels of low-density lipoprotein cholesterol (LDL-C; 109.4 ± 43.0 v 100.7 ± 48.8 mg/dL; P = .32). The LDL-C/HDL-C ratio was higher in patients compared to controls (4.0 ± 3.0 v 2.3 ± 1.7; P = .0001), as was the total cholesterol /HDL-C ratio (5.9 ± 3.5 v 3.9 ± 1.8; P = .0001). Compared to controls, stroke patients had higher fasting insulin levels (5.9 ± 5.4 v 2.3 ± 3.2 IU/mL; P < .001) and higher insulin resistance as measured by the homeostatic model assessment of insulin resistance (1.9 ± 2.2 v 0.7 ± 1.0; P = .001). Conclusions: Stroke is associated with markers of insulin resistance, low serum levels of HDL, and high total cholesterol/HDL ratio in this African population. Studies with a larger sample size and cohort designs are warranted to explore the causal pathways, persistence of these abnormalities, and population-specific cut points.
机译：背景：评估与喀麦隆医院环境中的第一中风集团相关的代谢谱的模式。方法：在6个月内录取第一寿命中风的所有患者有资格纳入该研究。 84％的参与率为68名患者的参与率为16％至85岁。选择五十七次对照受试者，将患者与年龄范围，性和已知的高血压和糖尿病患者相提并论。在入院后，我们在对照中测量了禁食血清葡萄糖，胰岛素和脂质，在第3天和第7天之间。结果：患者和对照组总胆固醇（172.6±39.5V，175.4±49.7mg / dl; p = .75），如甘油三酯（129.4±56.1V 122.4±60.7mg / dl; p = .53）。患者高密度脂蛋白胆固醇（HDL-C）水平低于对照（37.4±20.6V 50.2±18.0mg / dL; p = .001），具有相当水平的低密度脂蛋白胆固醇（LDL-C; 109.4±43.0 V 100.7±48.8 mg / dl; p = .32）。与对照相比，患者的LDL-C / HDL-C比率较高（4.0±3.0V 2.3±1.7; p = .0001），也是总胆固醇/ HDL-C比（5.9±3.5V 3.9±1.8; p = .0001）。与对照相比，中风患者的禁食胰岛素水平较高（5.9±5.4V 2.3±3.2 IU / mL; P <.001）和通过稳态模型抵抗的稳态模型评估测量的胰岛素抵抗更高（1.9±2.2 V 0.7±1.0 ; p = .001）。结论：中风与胰岛素抵抗的标记，低血清HDL水平，以及该非洲人群中的高总胆固醇/ HDL比。有更大的样本大小和队列设计的研究得到了探索因果途径，这些异常的持久性以及特定于人口的切割点。

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