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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >C-Reactive Protein Can Be an Early Predictor of Poststroke Apathy in Acute Ischemic Stroke Patients
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C-Reactive Protein Can Be an Early Predictor of Poststroke Apathy in Acute Ischemic Stroke Patients

机译：C-反应性蛋白可以是急性缺血性卒中患者口交肺体的早期预测因子

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Background: Apathy is a multidimensional syndrome referring to a primary lack of motivation that occurs frequently in survivors of stroke. Higher C-reactive protein (CRP) level was associated with higher apathy scores among Alzheimer disease cases. However, data on the relationship between CRP levels and apathy in patients with stroke are lacking. So, we hypothesized an association between CRP and poststroke apathy (PSA). Methods: Two hundred ninety-two consecutive patients with stroke were recruited within 7 days after stroke. Apathy symptoms were assessed at baseline and at 1, 3, and 6 months after stoke using the Apathy Evaluation Scale-Clinical (AES-C). Demographic and clinical information were obtained using the National Institutes of Health Stroke Scale (NIHSS) scores, Barthel Index (BI) scores, Mini-Mental State Examination (MMSE) scores, Hamilton Depression Scale (HAMD) scores, and Hamilton Anxiety Scale (HAMA) scores. CRP was measured at baseline. The presence and the location of infarcts were evaluated using magnetic resonance imaging. Results: Apathy at baseline was significantly associated with body mass index (BMI), NIHSS, BI, MMSE, HAMD, and CRP (P .05) upon admission. PSA at 6 months was significantly associated with elevated CRP concentrations, high AES-C score, and low BI score (P .05) upon admission. The AES-C scores peaked 3 months after stroke, but then abated over 6 months. Conclusions: CRP, BMI, MMSE, depression, and disability are closely related to apathy during the acute stage of ischemic stroke. Lower BI scores, higher CRP concentrations, and apathy in acute stroke phase increased the risk of PSA at 6 months.
机译：背景：冷漠是一种多维综合征，指的是初级缺乏动力，这些动力经常发生在中风的幸存者中。较高的C-反应蛋白（CRP）水平与阿尔茨海默病病例中的脾气暴躁程度较高有关。然而，缺乏关于卒中患者CRP水平和冷漠之间的关系的数据。因此，我们假设CRP和失败的冷漠（PSA）之间的关联。方法：卒中后7天内招募了两百九十两次卒中患者。使用冷漠评估标准临床（AES-C）在基线和1,3和6个月内评估脾气暴躁症状。使用国家卫生冲程量表（NIHSS）分数，Barthel指数（BI）评分，迷你精神状态检查（MMSE）分数，汉密尔顿抑郁症（HAMD）得分和汉密尔顿焦虑等级（HAMA）获得人口和临床信息）分数。 CRP在基线测量。使用磁共振成像评估梗塞的存在和位置。结果：在入院时，基线的冷漠与体重指数（BMI），NIHS，BI，MMSE，HAMD和CRP（P＆。05）显着相关。 6个月的PSA与CRP浓度，高AES-C评分和在入院时的低BI得分（P＆。05）明显相关。中风后3个月的AES-C分数达到达到峰值，但随后减少超过6个月。结论：CRP，BMI，MMSE，抑郁和残疾与缺血性卒中急性阶段的冷漠密切相关。急性卒中阶段降低BI分数，较高的CRP浓度，脾气暴躁，在6个月内增加了PSA的风险。

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