...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of substance abuse treatment >Effects of medication assisted treatment (MAT) for opioid use disorder on functional outcomes: A systematic review
【24h】

Effects of medication assisted treatment (MAT) for opioid use disorder on functional outcomes: A systematic review

机译：药物辅助治疗（MAT）对Opioid使用障碍对功能结果的影响：系统审查

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This systematic review synthesizes evidence on the effects of Medication-Assisted Treatment (MAT) for opioid use disorder (OUD) on functional outcomes, including cognitive (e.g., memory), physical (e.g., fatigue), occupational (e.g., return to work), social/behavioral (e.g., criminal activity), and neurological (e.g., balance) function.Five databases were searched from inception to July 2017 to identify English-language controlled trials, case control studies, and cohort comparisons of one or more groups; cross-sectional studies were excluded. Two independent reviewers screened identified literature, abstracted study-level information, and assessed the quality of included studies. Meta-analyses used the Hartung-Knapp method for random-effects models. The quality of evidence was assessed using the GRADE approach.A comprehensive search followed by 1411 full text publication screenings yielded 30 randomized controlled trials (RCTs) and 10 observational studies meeting inclusion criteria. The studies reported highly diverse functional outcome measures. Only one RCT was rated as high quality, but several methodologically sound observational studies were identified. The statistical power to detect differences in functional outcomes was unclear in most studies.When compared with matched “healthy” controls with no history of substance use disorder (SUD), in two studies MAT patients had significantly poorer working memory and cognitive speed. One study found MAT patients scored worse in aggressive responding than did “healthy” controls. A large observational study found that MAT users had twice the odds of involvement in an injurious traffic accident as non-users.When compared with persons with OUD not on MAT, one cohort study found lower fatigue rates among buprenorphine-treated OUD patients. No differences were reported for occupational outcomes and results for criminal activity and other social/behavioral areas were mixed.There were few differences among MAT drug types. A pooled analysis of three RCTs found a significantly lower prevalence of fatigue with buprenorphine compared to methadone, while a meta-analysis of the same RCTs found no statistical difference in insomnia prevalence. Three RCTs that focused on cognitive function compared the effects of buprenorphine to methadone; no statistically significant differences in memory, cognitive speed and flexibility, attention, or vision were reported.The quality of evidence for most functional outcomes was rated low or very low. In sum, weaknesses in the body of evidence prevent strong conclusions about the effects of MAT for opioid use disorder on functional outcomes. Rigorous studies of functional effects would strengthen the body of literature.
机译：这种系统评价综合了有关药物辅助治疗（MAT）对阿片类药物使用障碍（OUD）对功能结果的影响的证据，包括认知（例如，记忆），物理（例如疲劳），职业（例如，返回工作） ，社会/行为（例如，犯罪活动）和神经系统（例如，平衡）功能。从2017年7月开始搜查了一些数据库，以识别一个或多个群体的英语控制试验，案例控制研究和队列比较;排除横截面研究。两个独立的审稿人筛选了鉴定的文献，抽象的研究级信息，并评估了包括研究的质量。 Meta分析使用Hartung-Knapp方法进行随机效果模型。使用等级方法评估证据质量。综合搜索后，1411全文出版筛查产生了30个随机对照试验（RCT）和10项观察研究会议纳入标准。研究报告了高度多样化的功能结果措施。只有一个RCT被评为高质量，但确定了几项方法论上的几种方法。检测功能结果差异的统计学力量在大多数研究中尚不清楚。与没有物质使用障碍（SUD）历史的匹配的“健康”对照相比，在两项研究中，MAT患者的工作记忆和认知速度显着较差。一项研究发现乳头患者在侵略性应对中得分越来越差，而不是“健康”的控制。一个大型观察研究发现，席位用户患有两倍的伤害交通事故作为非用户的几率。与不在垫子上的人的人相比，一项队列研究发现丁丙诺啡治疗的oud患者中的疲劳率较低。没有报告职业结果的差异，犯罪活动和其他社会/行为地区的结果是混合的。乳头药物类型差异很少。与美沙酮相比，对三个RCT的汇集分析发现，与丁丙诺啡相比，脂肪酸疲劳的患病率显着降低，而同一RCT的荟萃分析发现没有失眠患病率差异。专注于认知功能的三个RCT与丁丙诺啡对美沙酮的影响比较了;报道了内存，认知速度和灵活性，关注或视力的统计学上没有统计学意义。大多数功能结果的证据质量被评为低或非常低。总而言之，证据体内的缺点可以防止关于垫的影响对阿片类药物使用障碍对功能结果的影响。对功能效应的严格研究将加强文学的身体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号