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首页> 外文期刊>Journal of the advanced practitioner in oncology >Assessment of Overall Survival Benefits in Patients Undergoing Complete Hepatectomy for Synchronous Colorectal Cancer With Liver and Lung Metastases
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Assessment of Overall Survival Benefits in Patients Undergoing Complete Hepatectomy for Synchronous Colorectal Cancer With Liver and Lung Metastases

机译：对肝肾转移术治疗结直肠癌完全肝切除术患者的整体生存益处的评估

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摘要

Overall survival (OS) is a statistical term referring to the percentage of a population in a group who are alive after a defined length of time, usually years. For example, a 5-year OS rate is the percentage of people who are alive 5 years after diagnosis or 5 years after the start of therapy. In surgical studies, OS is a universally accepted measure of direct benefit and can be easily and precisely measured. In general, OS is a common endpoint that is used to measure the success and efficacy of surgical treatments. In recent decades, surgical treatment of stage IV colorectal cancer has evolved considerably, allowing patients to have longer OS (Zisis et al, 2013). Furthermore, in patients undergoing hepatic resection, improvements in systemic therapy for stage IV colorectal cancer have significantly doubled the OS rate (Kim et al., 2012). Hepatectomy is now performed in 25% of patients with colorectal liver metastases (CLM), resulting in a 5-year OS rate up to 58% (Abdalla et al., 2004; Choti et al., 2002; Kopetz et al., 2009; Pawlik et al., 2005). Unfortunately, the remaining 75% of patients with CLM will not undergo hepatectomy, for reasons such as the presence of extrahepatic metastases, most commonly lung metastases (Hecht et al., 2009).
机译：总体生存（OS）是一种统计术语，指的是在规定的时间长度之后活着的人口中的人口百分比。例如，5年的OS率是诊断5年后的人的百分比或治疗开始5年。在手术研究中，OS是一种普遍接受的直接好处的衡量标准，可以轻松且精确地测量。通常，OS是一种共同的终点，用于测量手术治疗的成功和功效。近几十年来，阶段IV直肠癌的手术治疗已经显而易见，允许患者具有更长的OS（Zisis等，2013）。此外，在接受肝切除的患者中，OV结直肠癌阶段的系统性治疗的改善显着增加了OS率（Kim等，2012）。肝切除术现在以25％的结肠直肠肝转移患者（CLM）进行，导致5年的OS率高达58％（Abdalla等，2004; Choti等，2002; Kopetz等，2009 ; Pawlik等人，2005）。遗憾的是，由于诸如脱毛转移的存在，最常见的肺转移（Hecht等，2009），剩余的75％的CLM患者不会发生肝切除术。

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