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Review of a Study of Duloxetine for Painful Chemotherapy-Induced Peripheral Neuropathy

机译:审查脂肪化疗诱导的外周神经病变的杜洛汀研究

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Review of "Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy. A randomized clinical trial" by Smith et al (2013), Journal of the American Medical Association, 309, 1359-1367. For another perspective on the Smith et al. article as well as a discussion of challenges in conducting CIPN research, please see the related article by Constance Visovsky starting on page 369.he problem of chemotherapy-induced peripheral neuropathy (CIPN) has risen to the forefront for oncology professionals, who must pay greater attention to this distressing and potentially debilitating adverse effect than they did in the past. This is because CIPN may occur and even be dose limiting after several frequently used antineoplastic agents, including platinum analogs (most notably oxaliplatin and cisplatin), taxanes (especially paclitaxel), vinca alkaloids (e.g., vincristine), bort-ezomib (Velcade), and thalidomide (Thalomid).
机译:审查化疗诱导痛苦周围神经病变患者患者疼痛,功能和生活质量的“抗氧化甘油对生命的影响。”史密斯等人(2013年)的随机临床试验,“美国医学协会”,309,1359-1367 。 在史密斯等人的另一个透视图。 文章以及对开展CIPN研究中的挑战讨论,请参阅Contance Visovsky的相关文章,从第361页开始。Heaherapy诱导的外周神经病变(CIPN)的问题已上升到肿瘤学专业人员的最前沿,必须支付更高 注意这种令人痛苦和潜在的衰弱不良影响而不是过去。 这是因为在几种经常使用的抗肿瘤剂(包括铂类抗肿瘤剂(最符合较罕见的oxaliplatin和顺铂)中,紫杉烷(特别是紫杉醇),vinca生物碱(例如,vincristine),bort-ezomib(velcade), 和沙利度胺(丘脑)。

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