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首页> 外文期刊>Journal of the advanced practitioner in oncology >Beyond CAR T-Cell Therapy: Continued Monitoring and Management of Complications
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Beyond CAR T-Cell Therapy: Continued Monitoring and Management of Complications

机译：除了汽车T细胞疗法外：继续监测和管理并发症

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摘要

Chimeric antigen receptor (CAR) T-cell therapy has recently emerged as a groundbreaking treatment for CD19-expressing hematologic malignancies and received rapid approval by the U.S. Food & Drug Administration. Tisagenlecleucel and axicabtagene ciloleucel are now widely available at CAR T-cell therapy centers around the United States. Many patients have achieved complete response or remission despite failing multiple previous lines of therapy, but some patients endure the severe risks of cytokine release syndrome, neurotoxicity, and other immuno-logic effects. As more patients receive this therapy, they will present to their primary oncologists in the community setting for continued follow-up. Oncology-trained advanced practitioners must then have a working knowledge of CAR T-cell therapy, its toxicities, and follow-up care. This review presents the CAR T-cell therapy development and infusion process with associated immediate management. In addition, patient assessment and disease monitoring, relevant diagnostics, unique grading systems to CAR T-cell therapy toxicities, indications for hospitalization, infection prophylaxis, and management of nonneutro-penic and neutropenic fever are presented.
机译：最近嵌合抗原受体（汽车）T细胞疗法最近被赋予CD19表达血液学恶性肿瘤的突破性处理，并得到了美国食品和药物管理局的快速批准。 Tisagenlecleucel和AxicabTagene Ciloleucel现在广泛地提供在美国的汽车T细胞疗法中心。许多患者已经取得了完整的反应或缓解，尽管失败了多种前治疗，但有些患者忍受了细胞因子释放综合征，神经毒性和其他免疫逻辑效应的严重风险。随着更多患者接受这种治疗，它们将在社区环境中呈现给他们的主要肿瘤学家以进行继续进行后续行动。训练有素的高级从业者必须具有汽车T细胞治疗，毒性和随访的工作知识。本综述介绍了汽车T细胞疗法的开发和输液过程，具有相关立即管理。此外，提出了患者评估和疾病监测，相关诊断，独特的汽车T细胞治疗毒性，住院治疗，感染预防和非暴力和中性发热管理的适应症。

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