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首页> 外文期刊>Journal of the American Pharmacists Association: JAPhA >Exceeding the maximum daily dose of acetaminophen with use of different single-ingredient OTC formulations
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Exceeding the maximum daily dose of acetaminophen with use of different single-ingredient OTC formulations

机译：超出使用不同单成分OTC配方的最大日剂量的乙酰氨基酚

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ObjectivesTo assess whether there are differences in the likelihood of exceeding the daily limit of 4 grams of acetaminophen when using different formulations (325 mg, 500 mg, 650?mg) of OTC single-ingredient (SI) acetaminophen medications. Design and settingMultiyear observational study of acetaminophen use via daily online acetaminophen-usage diaries completed for 7 days. ParticipantsA total of 7579 U.S. adults from online research panels who used acetaminophen in the month preceding enrollment and used an OTC SI acetaminophen medication during the study. Outcome measureExceeding the daily dose. ResultsOn days when 325-mg or 500-mg OTC SI formulations were taken, users were not significantly more likely to exceed 4 grams than on days when OTC SI formulations were not used. On days when 650-mg extended-release (ER) formulations were taken, exceeding 4 grams was significantly more likely (8.9% of days vs. 4.4%;P< 0.0001; median on those days was 5.2 g) than on days with 325- or 500-mg OTC SI formulations. Users of 650-mg ER formulations were significantly less likely to know their dosing interval of 8 hours (33% vs. 49%;P?< 0.0001) and more likely to redose too soon (26% vs. 10%;P< 0.0001) and to use other acetaminophen medications concomitantly (14% vs. 7%;P< 0.0001). These patterns were strongest among 650-mg ER products that did not include “8-Hour” in the product name. ConclusionUsage of 500-mg OTC SI acetaminophen formulations does not contribute differently to exceeding dosage compared with other OTC SI acetaminophen formulations. Exceeding 4 grams is more likely when 650-mg ER formulations are used. Improved consumer information on the packages and counseling from pharmacists may help to reduce practices that contribute to exceeding the labeled daily limit of these medications.
机译：Objectivesto评估是否在使用不同配方（325mg，500mg，650μmg）的OTC单成分（Si）乙酰氨基酚药物时超过4克乙酰氨基酚的可能性存在差异。通过日常在线乙酰氨基酚使用日记完成乙酰氨基酚酚使用的设计和设定的设计和设定的观察性研究7天。参与者共有7579名美国成人来自在线研究小组，在前面的招生前使用乙酰氨基酚，并在研究期间使用OTC Si乙酰氨基酚类药物。结果是衡量日常剂量的结果。取出325毫克或500mg OTC Si配方的结果，用户在未使用OTC Si配方时的时间不会超过4克。在拍摄650毫克延长释放（ER）制剂时的日子里，超过4克的可能性（8.9％Vs.4％; P <0.0001;那些日中位数为5.2克）比325的日子 - 或500 mg OTC Si配方。 650 mg ER配方的用户显着不太可能知道其给药间隔为8小时（33％vs.49％;p≤0.0001），更容易过早染成（26％vs.10％; p <0.0001 ）和使用其他乙酰氨基酚药物（14％vs.7％; P <0.0001）。这些模式在650 mg ER产品中最强，在产品名称中不包括“8小时”。结论500mg OTC Si乙酰氨基酚制剂与其他OTC Si对乙酰氨基酚制剂相比的超出剂量不同。当使用650mg ER配方时，更可能超过4克。改善了关于包装的消费者信息和药剂师的咨询可能有助于减少有助于超过这些药物的标记日期的实践。

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