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首页> 外文期刊>Journal of pharmacy practice >Ticagrelor for Neuroendovascular Procedures: A Case Series
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Ticagrelor for Neuroendovascular Procedures: A Case Series

机译：神经血管手术的TiCagrelor：案例系列

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Background: The development of thromboembolism is one of the most common complications of neuroendovascular procedures. Although several small studies have deemed clopidogrel safe and effective in the prevention of intracranial stent thrombosis, ticagrelor has yet to be assessed in this setting. Objective: The objective of this study was to retrospectively evaluate the safety and efficacy of ticagrelor in patients undergoing neuroendovascular procedures. Methods: A retrospective review of patients receiving ticagrelor following neuroendovascular aneurysm repair. Results: A total of 5 patients undergoing neuroendovascular aneurysm repair received ticagrelor for a median of 5 days while hospitalized. Three patients were treated with stent-assisted coiling, while 2 received pipeline embolization devices. All patients received additional low-dose aspirin therapy. One patient received ticagrelor after experiencing a thrombotic event on clopidogrel, while a second patient was treated with ticagrelor after developing a dermatologic reaction to clopidogrel. Three (60%) patients were successfully treated and discharged on ticagrelor therapy. Two patients experienced cerebrovascular accidents following aneurysm repair while receiving ticagrelor, one of which was potentially due to medication omission. One (20%) patient receiving ticagrelor experienced a small retroperitoneal hematoma; however, ticagrelor therapy was continued without further complication. Conclusion: Therapy with ticagrelor may be a safe and effective treatment option for patients undergoing neuroendovascular aneurysm repair. However, future studies are warranted to substantiate these findings.
机译：背景：血栓栓塞的发展是神经血管手术中最常见的并发症之一。虽然几个小型研究被视为氯吡格雷，但在预防颅内支架血栓形成方面，尚未评估了TicagreloRes。目的：本研究的目的是回顾性地评估TicagreloLoLor对经受神经血管手术的患者的安全性和疗效。方法：对神经血管动脉瘤修复后接受TicagreloLor的回顾性综述。结果：共有5例接受神经养血管动脉瘤修复的患者，住院时5天的中位数。三名患者用支架辅助卷积处理，而2个接受的管道栓塞装置。所有患者均接受额外的低剂量阿司匹林疗法。在经历氯吡格雷的血栓形成事件后，一名患者接受了TiCagreler，而在向氯吡格雷发育皮肤病学反应后，用TiCagreloR处理第二患者。在TicagreloR疗法上成功地治疗和排放了三次（60％）患者。两名患者在接受TiCagreloLor时经历了动脉瘤修复后的脑血管意外，其中一个潜在的药物遗漏是可能的。接受TiCagreloLoR的一（20％）患者经历了小腹膜后血肿;然而，仍在继续进行TicagreloR治疗而无需进一步并发症。结论：对接受神经养血管动脉瘤修复的患者来说，TiCagreloR的治疗可能是一种安全有效的治疗选择。但是，未来的研究是有权证实这些调查结果。

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