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首页> 外文期刊>Journal of the American Academy of Nurse Practitioners. >Role of mTOR inhibition in the treatment of patients, with renal angiomyolipomas
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Role of mTOR inhibition in the treatment of patients, with renal angiomyolipomas

机译：MTOR抑制在治疗患者的作用，肾血管益紫外

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摘要

Purpose: To describe the role of mammalian target of rapamycin (mTOR) inhibition in the treatment of tuberous sclerosis complex (TSC) patients with renal angiomyolipoma in relation to available clinical data and clinical practice guidance for the nurse practitioner (NP). Data sources: A review of the scientific literature, key clinical congresses, and key clinical trials. Conclusions: TSC-associated renal angiomyolipomas have a propensity to grow over time and predispose patients to serious and life-threatening consequences. Surgery or invasive interventional therapies may not be the most optimal treatments because of the multiple, bilateral growth pattern of TSC-associated renal angiomyolipomas. Targeted therapies, such as mTOR inhibitors, which have demonstrated efficacy in maintaining and reducing renal angiomyolipoma size, are of great benefit to patients. Implications for practice: Treatment with everolimus, an oral mTOR inhibitor, offers patients a noninvasive pharmacotherapeutic treatment option. The NP, as a key member of the healthcare team overseeing TSC patients, must be knowledgeable about the safety and efficacy of mTOR inhibitors as their use in the patient population increases.
机译：目的：描述哺乳动物催乳素（MTOR）抑制在治疗肿瘤硬化症复合体（TSC）患者的肾血管眼血瘤患者的作用，与护士从业者（NP）的可用临床资料和临床实践指导有关。数据来源：对科学文献，关键临床大会和关键临床试验的审查。结论：TSC相关的肾血管眼脂肪症具有随着时间的推移而生长的倾向，促使患者严重和危及生命的后果。由于TSC相关的肾血管病症的多重双侧生长模式，手术或侵袭性介入治疗可能不是最佳的治疗方法。靶向疗法，例如MTOR抑制剂，其在维持和降低肾血小肿素瘤大小方面表现出疗效，对患者具有很大的益处。对实践的影响：用口腔MTOR抑制剂的everolimus治疗，为患者提供非侵入性药物治疗选择。作为监督TSC患者的医疗团队的主要成员，NP必须了解MTOR抑制剂的安全性和功效，因为它们在患者人口中的使用增加。

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