• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of science and medicine in sport >Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players
【24h】

Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players

机译：COL1A1基因内的基因变体与专业足球运动员中的前十字韧带损伤减少有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: To examine the association of the COL1A1 -1997G/T and +1245G/T polymorphisms, individually and as haplotypes, with anterior cruciate ligament ruptures in professional soccer players. Design: Subjects were 91 male professional soccer players with surgically diagnosed primary anterior cruciate ligament ruptures. The control group consisted of 143 apparently healthy male professional soccer players, who were without any self-reported history of ligament or tendon injury. Both subjects and healthy controls are from the same soccer teams, of the same ethnicity (Polish, East-Europeans for ≥3 generations), a similar age category, and had a comparable level of exposure to anterior cruciate ligament injury. Methods: Genomic DNA was extracted from the oral epithelial cells using GenElute Mammalian Genomic DNA Miniprep Kit (Sigma, Germany). All samples were genotyped using a Rotor-Gene real-time polymerase chain reaction. Results: Genotype distributions for both polymorphisms met the Hardy-Weinberg expectations in both subjects and controls (p>. 0.05). Higher frequency of the COL1A1 G-T (-1997G/T and +1245G/T polymorphisms) haplotype was significantly associated with reduced risk for anterior cruciate ligament rupture (Hap.score -1.98, p= 0.048). The TT genotype was under-represented in the anterior cruciate ligament rupture group. However, this result was not statistically significant (p= 0.084 Fisher's exact test, recessive mode: TT vs GT+GG). Conclusions: Higher frequency of the COL1A1 G-T haplotype is associated with reduced risk of anterior cruciate ligament injury in a group of professional soccer players. Consequently, carrying two copies the COL1A1 G-T haplotype may be protective against anterior cruciate ligament injury.
机译：目的：检查COL1A1 -1997G / T和+ 1245g / t多态性的关联，单独和作为单倍型，具有职业足球运动员的前十字韧带破裂。设计：受试者是91名男性专业足球运动员，手术诊断为初级前十字韧带破裂。对照组由143名显然是健康的男性职业足球运动员组成，没有任何自我报告的韧带或肌腱损伤。受试者和健康控制都是来自同一足球队，相同的种族（波兰，东欧人≥3代），类似年龄类别，并且具有相当的暴露水平的前令韧带损伤。方法：使用基因哺乳动物基因组DNA Miniprep套件（Sigma，Germany）从口腔上皮细胞中提取基因组DNA。使用转子基因实时聚合酶链反应进行所有样品进行基因分型。结果：两种多态性的基因型分布符合对象和控制中的Hardy-Weinberg期望（P> 0.05）。 Col1A1 G-T（-1997g / t和+ 1245g / t多态性的较高频率与前十字韧带破裂的风险降低显着相关（Hap.Score -1.98，P = 0.048）。 TT基因型在前十字韧带破裂组中表示。但是，此结果没有统计学意义（P = 0.084 Fisher的确切测试，隐性模式：TT与GT + GG）。结论：较高频率的COL1A1 G-T单倍型与一组专业足球运动员中的前十字韧带损伤的风险降低有关。因此，携带两份拷贝，Col1A1 G-T单倍型可以是保护抗前十字韧带损伤的保护性。

著录项

  • 来源
  • 作者

    FicekK.; CieszczykP.; KaczmarczykM.; Maciejewska-Kar?owskaA.; SawczukM.; CholewinskiJ.; Leonska-DuniecA.; Stepien-SlodkowskaM.; ZarebskaA.; SteptoN.K.; BishopD.J.; EynonN.;

  • 作者单位

    Galen Orthopaedics Bieruń Poland University of Szczecin Department of Physical Culture and;

    Academy of Physical Education and Sport Department of Sport Education Gdansk Poland;

    University of Szczecin Department of Physical Culture and Health Promotion Szczecin Poland;

    University of Szczecin Department of Genetics Szczecin Poland;

    University of Szczecin Department of Genetics Szczecin Poland;

    Galen Orthopaedics Bieruń Poland Boni Fratres Catoviensis Katowice Poland;

    University of Szczecin Department of Physical Culture and Health Promotion Szczecin Poland;

    University of Szczecin Department of Physical Culture and Health Promotion Szczecin Poland;

    Academy of Physical Education and Sport Department of Sport Education Gdansk Poland;

    Institute of Sport Exercise and Active Living (ISEAL) Victoria University Australia School of;

    Institute of Sport Exercise and Active Living (ISEAL) Victoria University Australia School of;

    Institute of Sport Exercise and Active Living (ISEAL) Victoria University Australia School of;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 运动医学;
  • 关键词

    ACL; Athletes; COL1A1; Genetic polymorphism; Soccer; Sport injuries;

    机译：ACL;运动员;COL1A1;遗传多态性;足球;运动伤害;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号