首页> 外文期刊>Journal of the American Association for Laboratory Animal Science >Genetic Characterization of a Captive Colony of Pigtailed Macaques (Macaca nemestrina)
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Genetic Characterization of a Captive Colony of Pigtailed Macaques (Macaca nemestrina)

机译:辫状猕猴的俘虏殖民地的遗传表征(Macaca Nemestrina)

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Effective colony management is critical to guarantee the availability of captive NHP as subjects for biomedical research. Pigtailed macaques (Macaca nemestrina) are an important model for the study of human and nonhuman primate diseases and behavior. Johns Hopkins University hosts one of the largest captive colonies of pigtailed macaques in the United States. In this study, we used 56 single-nucleotide polymorphisms (SNP) to characterize this population of pigtailed macaques, understand their population structure, and assess the effectiveness of their colony management. The results demonstrate that the colony has maintained a high level of genetic diversity, with no loss of heterozygosity since its origin, and low levels of inbreeding and genetic subdivision.
机译:有效的殖民地管理对于保证俘虏NHP作为生物医学研究的科目至关重要。 辫子猕猴(Macaca Nemestrina)是人类和非人类灵长类动物疾病和行为研究的重要模式。 约翰霍普金斯大学举办了美国最大的辫子猕猴的最大俘虏殖民地之一。 在这项研究中,我们使用了56种单核苷酸多态性(SNP)来表征猪染色猕猴的这种群体,了解他们的人口结构,并评估他们的殖民地管理的有效性。 结果表明,殖民地保持了高水平的遗传多样性,因为它的起源不损失,并且近亲繁殖和遗传细分水平低。

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