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首页> 外文期刊>Journal of the Chemical Society of Pakistan >Liquid Chromatographic Method for Simultaneous Determination of Citalopram with NSAIDs in Bulk Drug, Pharmaceutical Formulation and Human Serum
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Liquid Chromatographic Method for Simultaneous Determination of Citalopram with NSAIDs in Bulk Drug, Pharmaceutical Formulation and Human Serum

机译：液相色谱法同时测定散装药物，药物制剂和人血清中NSAID的CaliToPrAM

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摘要

A high performance liquid chromatographic method was developed and validated to simultaneously quantify citalopram with piroxicam, celecoxib and diclofenac sodium. Chromatographic analysis was performed at ambient temperature using Shimadzu Shim-pack CLC-ODS (M) 25M column linked to a UV-visible detector adjusted at 230 nm, employing 80:20 (v/v) methanol: water (pH 3.5) as mobile phase with flow rate 1.0 mL min(-1). Validation was performed in the ranges 0.6-20, 0.9-28, 0.6-20 and 1.0-32 mu g mL(- 1) with lowest level corresponding to detection limit 16.45, 23.33, 27.66 and 14.44 ng mL(-1) respectively. With-in the day precision ranged from 0.14-1.67% and between- day precision from 0.40-1.50%, accuracies were 99.61-100.86%. The analytes were successfully detected without any observable interference in pharmaceutical formulation and human serum samples demonstrating effectiveness of method.
机译：开发并验证了高性能液相色谱法，同时用吡罗昔康，Celecoxib和双氯芬酸钠量化西酞普兰。 在环境温度下使用Shimadzu Shim-Pack Clc-OD（M）25m柱在与230nm处调节的UV可见探测器连接的25m柱进行色谱分析，用80:20（v / v）甲醇：水（pH 3.5）为移动 流速的相1.0ml min（-1）。 验证在0.6-20,0.9-28,0.6-20和1.0-32μgml（ - 1）的范围内，分别对应于检测极限16.45,23.33,27.66和14.44ng ml（-1）的最低水平。 当天的精度范围为0.14-1.67％，介于白天的精度0.40-1.50％，精度为99.61-100.86％。 成功检测分析物而没有任何可观察到的药物制剂和人血清样品的干扰，证明了方法的有效性。

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