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首页> 外文期刊>Journal of the International Neuropsychological Society: JINS >Repeated Sport-Related Concussion Shows Only Minimal White Matter Differences Many Years After Playing High School Football
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Repeated Sport-Related Concussion Shows Only Minimal White Matter Differences Many Years After Playing High School Football

机译：重复的运动相关的脑震荡显示在播放高中橄榄球后多年的最小白质差异

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Objective: Multiple concussions sustained in youth sport may be associated with later-life brain changes and worse cognitive outcomes. We examined the association between two or more concussions during high school football and later-life white matter (WM) microstructure (i.e., 22–47 years following football retirement) using diffusion tensor imaging (DTI). Method: Forty former high school football players aged 40–65 who received 2+ concussions during high school football (N = 20), or denied concussive events (N = 20) were recruited. Participants underwent neurocognitive testing and DTI scanning. Results: Groups did not statistically differ on age, education, or estimated pre-morbid intelligence. Tract-based Spatial Statistics (TBSS) correcting for Family-Wise Error (FWE)(p < .05) did not yield differences between groups at the whole-brain level. Region of interest analyses showed higher mean diffusivity (MD) in the anterior limb of the internal capsule (ALIC) in the concussed group compared to the non-concussed former players. More liberal analyses (i.e., p < .001, uncorrected for multiple comparisons, ≥8 voxels) also revealed that former players endorsing 2+ concussions had higher MD in the ALIC. Analyses that covaried for age did not reveal differences at either threshold. Concussive histories were not associated with worse cognitive functioning, nor did it impact the relationship between neuropsychological scores and DTI metrics. Discussion: Results suggest only minimal neuroanatomical brain differences in former athletes many years following original concussive injuries compared to controls.
机译：目的：青年运动中持续的多次脑震荡可能与后病人的大脑变化和更糟糕的认知结果相关。我们使用扩散张量成像（DTI）在高中足球和后续白蚁（WM）微观结构（即，22-47岁以下）之间进行了两个或更多次脑震荡之间的关联。方法：40-65岁的前任高中足球运动员在高中足球（N = 20）期间收到了2+乐震震荡，或被剥夺了震动事件（n = 20）。参与者接受了神经认知测试和DTI扫描。结果：年龄，教育或估计的病态智力，小组没有统计学。校正家庭明智误差（FWE）（P <.05）的基于轨道的空间统计（TBS）在全脑水平之间没有产生群体之间的差异。与非展示的前球员相比，兴趣分析区域在展示组内胶囊（ALIC）的前肢中的平均扩散率（MD）更高。更多的自由分析（即，P <.001，对多重比较，≥8voxels的未校正）还透露，前者在ALIC中获得2+震荡的前参赛者在较高的MD。分析调配年龄的分析没有揭示任何一个阈值的差异。巨大历史与更严重的认知功能无关，它没有影响神经心理学评分与DTI度量之间的关系。讨论：结果表明，与对照组相比，原始轰炸机多年来，前运动员的神经杀虫剂差异最小。

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