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首页> 外文期刊>Journal of the experimental analysis of behavior >Neuronal substrates of relapse to cocaine-seeking behavior: Role of prefrontal cortex
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Neuronal substrates of relapse to cocaine-seeking behavior: Role of prefrontal cortex

机译：寻求可卡因行为的神经元底物：前额叶皮质的作用

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The return to drug seeking, even after prolonged periods of abstinence, is a defining feature of cocaine addiction. The neural circuitry underlying relapse has been identified in neuropharmacological studies of experimental animals, typically rats, and supported in brain imaging studies of human addicts. Although the nucleus accumbens (NAcc), which has long been implicated in goal-directed behavior, plays a critical role in this circuit, the prefrontal cortex (PFC) appears to process the events that directly trigger relapse: exposure to acute stress, cues previously associated with the drug, and the drug itself In this paper, we review animal models of relapse and what they have revealed about the mechanisms underlying the involvement of the NAcc and PFC in cocaine-seeking behavior. We also present electrophysiological data from PFC illustrating how the hedonic, motor, motivational, and reinforcing effects of cocaine can be analyzed at the neuronal level. Our preliminary findings suggest a role for PFC in processing information related to cocaine seeking but not the hedonic effects of the drug. Further use of this recording technology can help dissect the functions of PFC and other components of the neural circuitry underlying relapse.
机译：返回药物寻求，即使在长时间的禁欲之后，也是可卡因成瘾的定义特征。在实验动物的神经药物研究中鉴定了神经电路复发，通常是大鼠的神经医学研究，并支持人类成瘾者的脑成像研究。虽然核心对手（NACC）长期以来一直涉及目标定向行为，但在该电路中发挥着关键作用，似乎是前额定皮层（PFC）来处理直接触发复发的事件：暴露于急性压力，之前提示本文审查了药物和药物本身，我们审查了复发的动物模型以及他们透露了关于NACC和PFC参与在可卡因寻求行为中的机制的机制。我们还从PFC呈现电生理数据，说明在神经元水平的分析可卡因的蜂窝，电动机，诱导和增强效果如何。我们的初步调查结果表明了PFC在与可卡因寻求相关的信息中的PFC的作用，但不是药物的蜂窝效应。进一步使用该记录技术可以帮助解剖PFC和神经电路的其他组件的功能。

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