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首页> 外文期刊>Journal of the Indian Chemical Society >Status of urinary porphyrins and inverse correlation of porphyrins with serum B vitamins in arsenic endemic area of West Bengal, India
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Status of urinary porphyrins and inverse correlation of porphyrins with serum B vitamins in arsenic endemic area of West Bengal, India

机译：印度西孟加拉邦砷地方区血清B维生素卟啉尿素卟啉及逆相关性

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Chronic arsenic toxicity through drinking water is still one of the major problems across the world. Bangladesh and India (particularly the state of West Bengal) are the worst affected countries with such problem. Millions of people all over the world are affected by arsenic related diseases. In our study, concentration of ground water arsenic, urine arsenic, hair arsenic and nail arsenic from adult individuals were measured from exposed areas of West Bengal, India respectively by flow injection atomic spectroscopy and transversely heated graphite atomiser techniques. Porphyrins, uroporphyrin III, heptacarboxyporphyrin I, hexacarboxyporphyrin I, pentacarboxyporphyrin I, coproporphyrin III in urine were analysed separately by HPLC using fluorescence detector as well as level of vitamin B-6, vitamin B-9 and vitamin B-12 were carried out in serum samples among the population in the selected area in North 24-Parganas, West Bengal, India. Concentration of uro III, hepta I, copro III and copro III/uro III were observed to increase irrespective of gender and also in total; whereas level of B vitamins were found to decrease with increase in exposure to arsenic contaminated drinking water from underground sources. The difference of vitamin B-6 (p 0.01) between the population exposed to 50 and 50 mu g/L arsenic in drinking water was found to be significant. Significant difference was also noticed in case of uro III (p 0.05), copro III (p 0.01) and copro III/uro III (p 0.05) between two exposure categories. This study demonstrated increasing tendency in urinary porphyrins as well as inverse relationships of serum B vitamins with increased water arsenic concentration.
机译：通过饮用水慢性砷毒性仍然是世界各地的主要问题之一。孟加拉国和印度（特别是西孟加拉邦国家）是受此类问题的最严重影响的国家。全世界数百万人受砷相关疾病的影响。在我们的研究中，通过流动喷射原子谱分别通过流动注射原子谱和横向加热的石墨雾化器技术从西孟加拉邦的暴露区域测量来自成人个体的地下水，尿砷，毛砷和指甲砷的浓度。使用荧光探测器分别通过HPLC分别通过HPLC分别通过HPLC分别通过HPLC分离尿嘧啶，尿囊羧卟啉I，六世羧基卟啉I，六种羧脲III，尿液中的尿卟啉III，维生素B-6水平，维生素B-9和维生素B-12在血清中进行印度西孟加拉邦北部24杆北部的选定区域中的人口中的样本。不管性别而且，都观察到URO III，庚酮III，庚晕III和普通III / URO III的浓度，而且还增加了性别。虽然B族维生素的水平随着来自地下来源的砷污染饮用水的暴露而降低。发现暴露于50和50μmg/ l砷中的群体之间的维生素B-6（P <0.01）的差异是显着的。在两个曝光类别之间的URO III（P <0.05），COPRO III（P <0.01）和COPO III / URO III（P <0.05）之间也有显着差异。该研究表明尿卟啉的趋势越来越大，以及血清B维生素随着水砷浓度增加的反相关系。

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