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首页> 外文期刊>Journal of the Indian Chemical Society >Simultaneous estimation of thiocolchicoside and ketorolac tromethamine using UV spectroscopy
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Simultaneous estimation of thiocolchicoside and ketorolac tromethamine using UV spectroscopy

机译：用UV光谱同时估计硫核苷酸和Ketorolac Tromethamine

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摘要

Thiocolchicoside and ketorolac are potent anti-inflammatory and pain relieving agents. They impart synergistic action when delivered in combination. In the present study a simple accurate, precised and sensitive method was developed for the simultaneous estimation of both drugs. The drug thiocolchicoside and ketorolac have absorption maxima at 259 nm and 323 nm respectively. Both of the drugs in the proposed method showed linearity in the range of 5-25 mu g/mL with an r(2) value of 0.997. The accuracy study results data showed recovery of the standard drug in the range 'of 98.84-100.67% with a standard deviation of 0.92 for thiocolchicoside and 98.20-101.69% with a standard deviation of 1.96 for ketorolac. Intra-day and inter-instrument variability study results also found within the standard limits, showing the precision of the methodology. The LOD and LOQ values for thiocolchicoside was 1.11 and 3.390 mu g/ml, respectively, whereas, the LOD and LOQ values for ketorolac were 0.986 and 2.99 mu g/ml, respectively. Thus, it could be concluded that the developed method was accurate, precised, specific with enough sensitive and successfully implied for the simultaneous estimation of thiocolchicoside and ketorolac in their combined dosage during the routine analysis work.
机译：硫核苷酸和Ketorolac是有效的抗炎和疼痛缓解剂。它们在组合交付时赋予协同作用。在本研究中，开发了一种简单的准确，精确的方法，用于同时估计两种药物。药物硫核苷酸和酮溶胶分别具有259nm和323nm的吸收最大值。所提出的方法中的两种药物显示在5-25μg/ ml的范围内的线性，R（2）值为0.997。准确性研究结果数据显示了98.84-100.67％的标准药物的回收率，其标准偏差为0.92的硫核苷酸，98.20-101.69％，标准偏差为酮洛克。日内和仪器间可变性研究结果也在标准限度内发现，显示了方法的精度。分别为硫核苷酸的LOD和LOQ值分别为1.11和3.390μg/ ml，而酮溶胶的LOD和LOQ值分别为0.986和2.99μg/ ml。因此，可以得出结论，发育方法精确，比特异性足够敏感，并成功地暗示在常规分析工作期间在其组合剂量中同时估计硫核苷酸和Ketorolac。

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