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首页> 外文期刊>Journal of the Indian Chemical Society >Microwave irradiation in organic synthesis towards the construction of biologically active N-heterocycles
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Microwave irradiation in organic synthesis towards the construction of biologically active N-heterocycles

机译：微波辐射有机合成朝向生物活性N-杂环的构建

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摘要

In the past few years, using microwave energy to heat and drive chemical reactions has become progressively more popular theme in the scientific community. Microwave-assisted organic synthesis is proving to be instrumental in the rapid synthesis of compounds with novel and improved biological activities. An efficiency of 'microwave flash heating' for chemical synthesis is the spectacular reduction in reaction times from days and hours to minutes and seconds, higher yields under milder reaction conditions, and higher product purities etc. Multicomponent reactions are precious tools for the making of various N-heterocycles and the N-heterocyclic scaffolds represent the central framework of many biologically active compounds. N-containing heterocycles hold a special place among pharmaceutically significant natural products and synthetic compounds needed for any developed human society. In the fields of organic chemistry, microwave irradiation is rapidly substituted the conventional heating methods in the world of multicomponent chemistry. In this review, we discuss only formation of N-containing heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions.
机译：在过去的几年里，使用微波能量来热量和推动化学反应在科学界中变得逐渐更受欢迎。微波辅助的有机合成在于在具有新颖和改进的生物活性的快速合成化合物中是有乐的。化学合成的“微波闪光加热”的效率是反应时间从天和数小时到几分钟的壮观降低，更高的产量下降，更高的产量，更高的产品纯度等。多组分反应是制造各种的珍贵工具N-杂环和N-杂环支架代表许多生物活性化合物的中心框架。含N的杂环在任何发育的人类社会所需的药学上有显着的天然产物和合成化合物中占有特殊的位置。在有机化学领域，微波辐射迅速取代了多组分化学世界的常规加热方法。在本文中，我们仅使用现代有机转化在微波活化下讨论含N含氮的杂环化合物及其稠合的类似物，包括环偶，环形加法，多组分和其他模块化反应。

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