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首页> 外文期刊>Journal of Veterinary Dentistry >Diagnostic Yield of Micro-Computed Tomography (micro-CT) Versus Histopathology of a Canine Oral Fibrosarcoma
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Diagnostic Yield of Micro-Computed Tomography (micro-CT) Versus Histopathology of a Canine Oral Fibrosarcoma

机译：微观计算机断层扫描（Micro-CT）的诊断产量与犬口腔纤维肉瘤的组织病理学

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Micro-computed tomography (micro-CT) imaging currently gains increased interest in human as well as veterinary medicine. The ability to image 3-dimensional (3D) biopsy specimens nondestructively down to 1 mu m spatial resolution makes it a promising tool for microscopic tissue evaluation in addition to histopathology. Visualizing tumor margins and calculating tumor load on 3D reconstructions may also enhance oncological therapies. The objective of this study was to describe the workflow from tumor resection to histopathological diagnosis, using both routine hematoxylin-eosin (HE)-stained sections and micro-CT tomograms on a stage II oral fibrosarcoma in a 7-year-old Hovawart dog. The maxillectomy specimen was fixed with formalin and stained with an X-ray dense soft tissue contrast agent. Micro-CT imaging was done using an ex vivo specimen micro-CT device. Tumor margins could not be exactly determined on micro-CT tomograms due to limited image resolution and contrast. Histopathology was performed after washing out the contrast agent. It showed neoplastic cells infiltrating the surrounding tissue further than assumed from micro-CT images. A total tumor volume of 10.3 cm(3) could be calculated based on correlating micro-CT tomograms with HE-stained sections. This correlative approach may be of particular interest for oncological therapy. More than that, micro-CT imaging technology supported histopathology by means of 3D orientation and selection of slices to be cut on determining tumor margins. In this clinical case report, micro-CT imaging did not provide unambiguous clinical evidence for oncological decision-making, but it showed potential to support histopathology and calculate tumor volume for further clinical use.
机译：微计算机断层扫描（Micro-CT）成像目前增加了对人类和兽医的兴趣。除了组织病理学之外，对1 mu m空间分辨率无损到1μm空间分辨率的3维（3D）活检标本的能力使其成为微观组织评估的有希望的工具。可视化肿瘤余量并计算3D重建的肿瘤载荷也可能增强肿瘤学疗法。本研究的目的是描述肿瘤切除对组织病理学诊断的工作流程，使用常规的血毒素 - 曙红（HE） - 在一个7岁的Hovawart Dog中的II阶段口腔纤维肉瘤上进行染色的部分和微型CT断层照片。通过福尔马林固定颌面切除术，并用X射线致密软组织造影剂染色。使用离体样品Micro-CT器件进行微型CT成像。由于图像分辨率有限和对比度，在微型CT断层照片上无法精确确定肿瘤余量。洗涤造影剂后进行组织病理学。它显示出渗透到周围组织的肿瘤细胞，比来自微CT图像的假设进一步渗透。可以基于将微型CT断层照片与HE-STAIS部分相关的微型CT断层照片来计算10.3cm（3）的总肿瘤体积。这种相关性方法可能特别感兴趣的肿瘤治疗。超过这一点，通过3D方向和选择在确定肿瘤边距来切割的三维方向和切片选择的微型CT成像技术。在该临床报告中，微型CT成像未提供肿瘤决策的明确临床证据，但它显示出支持组织病理学并计算肿瘤体积以进一步临床使用。

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