Vascular beds maintain pancreatic tumour explants for ex vivo drug screening

Bazou Despina; Maimon Nir; Gruionu Gabriel; Grahovac Jelena; Seano Giorgio; Liu Hao; Evans Conor L.; Munn Lance L.

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Vascular beds maintain pancreatic tumour explants for ex vivo drug screening

机译：血管床维持胰腺肿瘤外植体进行离体药物筛查

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Our understanding of cancer progression or response to therapies would benefit from benchtop, tissue-level assays that preserve the biology and anatomy of human tumours ex vivo. We present a methodology for maintaining patient tumour samples ex vivo for the purpose of drug testing in a clinical setting. The harvested tumour biopsy, excised from mice or patients, is integrated into a support tissue that includes stroma and vasculature. This support tissue preserves tumour histoarchitecture and relevant expression profiles, and tumour tissues cultured using this system display different sensitivities to chemotherapeutics compared with tumour explants with no supporting tissue. The methodology is more rapid than patient-derived xenograft models, easy to implement, and amenable to high-throughput assays, making it an attractive tool for in vitro drug screening or for the guidance of patient-specific chemotherapies.

机译：我们对癌症进展或对疗法反应的理解将受益于维护人肿瘤的生物学和解剖学的组织水平测定。我们提出了一种在临床环境中维持患者肿瘤样品的方法，以便在临床环境中进行药物检测。从小鼠或患者切除的收获的肿瘤活组织检查集成到包括基质和脉管系统的支撑组织中。该支持组织保留肿瘤组织结构和相关的表达型材，并且使用该系统培养的肿瘤组织与没有支撑组织的肿瘤外植物相比，与化学治疗剂相比显示不同的敏感性。该方法比患者衍生的异种移植型号更快，易于实施，并且适用于高通量测定，使其成为体外药物筛选的有吸引力的工具或用于患者特异性化学疗法的指导。

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来源
《Journal of tissue engineering and regenerative medicine》 |2018年第1期|共5页
作者
Bazou Despina; Maimon Nir; Gruionu Gabriel; Grahovac Jelena; Seano Giorgio; Liu Hao; Evans Conor L.; Munn Lance L.;
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作者单位

Harvard Med Sch Massachusetts Gen Hosp Dept Radiat Oncol Boston MA USA;

Harvard Med Sch Massachusetts Gen Hosp Dept Radiat Oncol Boston MA USA;

Harvard Med Sch Massachusetts Gen Hosp Dept Surg Boston MA USA;

Harvard Med Sch Massachusetts Gen Hosp Dept Radiat Oncol Boston MA USA;

Harvard Med Sch Massachusetts Gen Hosp Dept Radiat Oncol Boston MA USA;

Harvard Med Sch Massachusetts Gen Hosp Dept Radiat Oncol Boston MA USA;

Harvard Med Sch Massachusetts Gen Hosp Wellman Ctr Photomed Charlestown MA USA;

Harvard Med Sch Massachusetts Gen Hosp Dept Radiat Oncol Boston MA USA;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
cancer; chemotherapy; high-throughput assay; pancreatic; tumour explant; vascular bed; vascularization;

机译：癌症;化疗;高通量测定;胰腺;肿瘤外植体;血管床;血管化;

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专利

1. Vascular beds maintain pancreatic tumour explants for ex vivo drug screening [J] . Bazou Despina, Maimon Nir, Gruionu Gabriel, Journal of tissue engineering and regenerative medicine . 2018,第1期

机译：血管床维持胰腺肿瘤外植体进行离体药物筛查
2. Development of a Screening Strategy for Prediction of Drug-Induced Vascular Injury (DIVI): Creation of a DIVI Database and Compound Screening to Evaluate Translation and Predictivity of In Vitro and Ex Vivo Assays [J] . Wisialowski T., Fensome A., Fish D., International journal of toxicology . 2017,第1期

机译：制定药物诱导血管损伤预测的筛选策略（DIVI）：创建DIVI数据库和复合筛查，以评估体外和前体内测定的平移和预测性
3. A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform [J] . Andrew Riley, Victoria Green, Ramsah Cheah, BMC Cancer . 2019,第1期

机译：一种能够维持功能性甲状腺癌样品的新型微流体装置，例如新的药物筛查平台
4. Application Of Multiphoton steady state and lifetime imaging to mapping of tumour vascular architecture in vivo [C] . S. M. Ameer-Beg, P. R. Barber, R. J. Hodgkiss, Conference on Multiphoton Microscopy in the Biomedical Sciences Ⅱ Jan 20-22, 2002 San Jose, USA . 2002

机译：多光子稳态和寿命成像在体内肿瘤血管结构定位中的应用
5. Investigations of the biodistribution and phototherapeutic utility of two palladium(II)-containing macrocyclic drugs in a tumour-bearing mouse model: A study of the pharmacokinetics and tissue distribution of the potential photodynamic drug palladium-bacteriopheophorbide as well as the in vivo treatment efficacy and tissue distribution of the potential photothermal drug palladium(II) octabutoxynaphthalocyanine. [D] . DeGroot, Jennifer Leanne. 2002

机译：两种含钯（II）的大环药物在荷瘤小鼠模型中的生物分布和光疗实用性的研究：潜在的光动力药物钯-细菌脱镁叶绿酸的药代动力学和组织分布以及体内治疗效果和研究光热药物钯（II）八丁氧基萘酞菁的组织分布。
6. Vascular beds maintain pancreatic tumor explants for ex vivo drug screening [O] . Despina Bazou, Nir Maimon, Gabriel Gruionu, -1

机译：血管床保持胰腺肿瘤外植体用于离体药物筛选
7. Vascular beds maintain pancreatic tumour explants for ex vivo drug screening [O] . Despina Bazou, Nir Maimon, Gabriel Gruionu, 2017

机译：血管床维持胰腺肿瘤外植体进行离体药物筛查

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Vascular beds maintain pancreatic tumour explants for ex vivo drug screening

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