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首页> 外文期刊>Journal of tissue engineering and regenerative medicine >Electrospun nanofibres to mimic natural hierarchical structure of tissues: application in musculoskeletal regeneration
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Electrospun nanofibres to mimic natural hierarchical structure of tissues: application in musculoskeletal regeneration

机译:Electrom an纳米纤维以模拟组织的自然等级结构:在肌肉骨骼再生中的应用

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摘要

Biomimetic scaffolds mimicking the natural hierarchical structure of tissues have recently attracted the interest of researchers and provide a promising strategy to resemble the nonhomogeneous property of tissues. This review provides an overview of the various hierarchical length scales in the native tissues of the musculoskeletal system. It further focuses on electrospinning as a technique to mimic the tissue structures with specific emphasis on bone. The effect of cellular alignment, infiltration, vascularisation, and differentiation in these nanostructures has also been discussed. An outline of the various additive manufacturing techniques in combination with electrospinning has been elaborated. The review concludes with the challenges and future directions to understand the intricacies of bottom-up approach to engineer the systems at a macroscale. Copyright (C) 2016 John Wiley & Sons, Ltd.
机译:模仿组织自然等级结构的仿生支架最近吸引了研究人员的兴趣,并提供了一种类似于组织的非均匀性的策略。 该综述概述了肌肉骨骼系统的本机组织中的各种层次长度尺度的概述。 它进一步侧重于静电纺丝作为模拟具有特异性强调骨骼的组织结构的技术。 还讨论了细胞取向,浸润,血管异构化和这些纳米结构中的分化的影响。 已经详细阐述了各种添加剂制造技术的概要,并阐述了静电纺丝的组合。 审查结束了挑战和未来方向,了解在宏观上工程系统的自下而上方法的复杂性。 版权所有(c)2016 John Wiley&Sons,Ltd。

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