Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors

del Valle Jaume; Santos Daniel; Delgado-Martinez Ignacio; de la Oliva Natalia; Giudetti Guido; Micera Silvestro; Navarro Xavier

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Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors

机译：通过将细胞外基质组分与神经营养因子组合来再生通过双组分的电动机和感觉轴突的分离

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摘要

Segregation of regenerating motor and sensory axons may be a good strategy to improve selective functionality of regenerative interfaces to provide closed-loop commands. Provided that extracellular matrix components and neurotrophic factors exert guidance effects on different neuronal populations, we assessed in vivo the potential of separating sensory and motor axons regenerating in a bicompartmental Y-type tube, with each branch prefilled with an adequate combination of extracellular matrix and neurotrophic factors.

机译：再生电动机和感觉轴突的分离可能是改善再生接口的选择性功能以提供闭环命令的良好策略。提供细胞外基质组分和神经营养因素对不同的神经元群体产生引导效应，我们在体内评估了分离在双组分Y型管中再生的感觉和电动机轴突的电位，每个分支预先填充细胞外基质和神经营养的足够组合因素。

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来源
《Journal of tissue engineering and regenerative medicine》 |2018年第4期|共10页
作者
del Valle Jaume; Santos Daniel; Delgado-Martinez Ignacio; de la Oliva Natalia; Giudetti Guido; Micera Silvestro; Navarro Xavier;
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作者单位

Univ Autonoma Barcelona Inst Neurosci Bellaterra Spain;

Univ Autonoma Barcelona Inst Neurosci Bellaterra Spain;

Univ Autonoma Barcelona Inst Neurosci Bellaterra Spain;

Univ Autonoma Barcelona Inst Neurosci Bellaterra Spain;

Scuola Super Sant Anna Biorobot Inst Pontedera Italy;

Scuola Super Sant Anna Biorobot Inst Pontedera Italy;

Univ Autonoma Barcelona Inst Neurosci Bellaterra Spain;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
axon regeneration; axonal guidance; extracellular matrix; motor axons; neurotrophic factors; sensory axons; Y-tube;

机译：轴突再生;轴突引导;细胞外基质;运动轴突;神经营养因素;感觉轴突;Y管;

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专利

1. Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors [J] . del Valle Jaume, Santos Daniel, Delgado-Martinez Ignacio, Journal of tissue engineering and regenerative medicine . 2018,第4期

机译：通过将细胞外基质组分与神经营养因子组合来再生通过双组分的电动机和感觉轴突的分离
2. Preferential Enhancement of Sensory and Motor Axon Regeneration by Combining Extracellular Matrix Components with Neurotrophic Factors [J] . Daniel Santos, Francisco González-Pérez, Guido Giudetti, International Journal of Molecular Sciences . 2017,第1期

机译：通过结合细胞外基质成分和神经营养因子，优先增强感觉和运动轴突的再生。
3. Differential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerve. [J] . Tannemaat MR, Eggers R, Hendriks WT, The European Journal of Neuroscience . 2008,第8期

机译：慢病毒载体介导的神经生长因子和胶质细胞源性神经营养因子过表达对横断周围神经再生感觉轴突和运动轴突的差异作用。
4. Ile-Lys-Val-Ala-Val and Leu-Arg-Glu peptide signaling in combination with matrix metalloprotease cleavable erosslinkers alter extracellular matrix degrading enzyme expression and axon extension in encapsulated human induced pluripotent stem cell derived neural stem cells. [C] . T. Hiran Perera, Laura A. Smith Callahan Society for Biomaterials annual meeting and exposition . 2019

机译：Ile-Lys-Val-Ala-Val和Leu-Arg-Glu肽信号转导与基质金属蛋白酶可切割的erosslinker结合改变封装的人诱导多能干细胞衍生的神经干细胞中细胞外基质降解酶的表达和轴突延伸。
5. Neurotrophic factor combinations and extracellular matrix-based hydrogels for nerve regeneration. [D] . Deister, Curt Andrew. 2007

机译：神经营养因子组合和基于细胞外基质的水凝胶用于神经再生。
6. Preferential Enhancement of Sensory and Motor Axon Regeneration by Combining Extracellular Matrix Components with Neurotrophic Factors [O] . Daniel Santos, Francisco González-Pérez, Guido Giudetti, 2017

机译：通过结合细胞外基质成分和神经营养因子优先增强感觉和运动轴突的再生。
7. Preferential enhancement of sensory and motor axon regeneration by combining extracellular matrix components with neurotrophic factors [O] . Santos, Daniel 2017

机译：通过结合细胞外基质成分和神经营养因子，优先增强感觉轴突和运动轴突再生

Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors

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