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首页> 外文期刊>Journal of toxicology and environmental health, Part B. Critical reviews >NEUROENDOCRINE EFFECTS OF ENDOCRINE DISRUPTORS IN TELEOST FISH
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NEUROENDOCRINE EFFECTS OF ENDOCRINE DISRUPTORS IN TELEOST FISH

机译：神经内分泌物在远程鱼中的神经内分泌作用

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摘要

Because a large proportion of potential endocrine disrupters (EDC) end up in surface waters, aquatic species are particularly vulnerable to their potential adverse effects. Recent studies identified a number of brain targets for EDC commonly present in environmentally relevant concentrations in surface waters. Among those neuronal systems disrupted by EDC are the gonadotropin-releasing hormone (GnRH) neurons, the dopaminergic and serotoninergic circuits, and more recently the Kiss/GPR54 system, which regulates gonadotropin release. However, one of the most striking effects of EDC, notably estrogen mimics, is their impact on the cyp19a1b gene that encodes the brain aromatase isoform in fish. Moreover, this is the only example in which the molecular basis of endocrine disruption is fully understood. The aims of this review were to (1) synthesize the most recent discoveries concerning the EDC effects upon neuroendocrine systems of fish and (2) provide, when possible, the underlying molecular basis of disruption for each system concerned. The potential adverse effects of EDC on neurogenesis, puberty, and brain sexualization are also described. It is important to point out the future environmental, social, and economical issues arising from endocrine disruption studies in the context of risk assessment.
机译：由于大部分潜在的内分泌破坏剂（EDC）最终在表面水域中，水生物物种特别容易受到它们潜在的不利影响。最近的研究鉴定了常规存在于表面水域环境相关浓度的EDC的许多脑靶标。在由EDC中断的那些神经元系统中，是促性腺激素释放的激素（GNRH）神经元，多巴胺能和血清酮，以及最近的吻/ GPR54系统，调节促性腺激素释放。然而，EDC最引人注目的效果之一，特别是雌激素模拟物，它们对CYP19A1B基因的影响，该基因编码了鱼类的脑芳香酶同种型。此外，这是唯一可以完全理解内分泌破坏的分子基础的唯一举例。本综述的目的是（1）合成有关鱼类神经内分泌系统的EDC效应的最新发现，（2）提供，当可能的每个系统的中断的潜在分子基础提供潜在的分子基础。还描述了EDC对神经发生，青春期和大脑性化的潜在不利影响。重要的是指出，在风险评估的背景下指出内分泌破坏研究产生的未来环境，社会和经济问题。

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