• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of toxicology and environmental health, Part B. Critical reviews >THE FUTURE OF TOXICITY TESTING
【24h】

THE FUTURE OF TOXICITY TESTING

机译：毒性测试的未来

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In 2007, the U.S. National Research Council (NRC) released a report, "Toxicity Testing in the 21st Century: A Vision and a Strategy," that proposes a paradigm shift for toxicity testing of environmental agents. The vision is based on the notion that exposure to environmental agents leads to adverse health outcomes through the perturbation of toxicity pathways that are operative in humans. Implementation of the NRC vision will involve a fundamental change in the assessment of toxicity of environmental agents, moving away from adverse health outcomes observed in experimental animals to the identification of critical perturbations of toxicity pathways. Pathway perturbations will be identified using in vitro assays and quantified for dose response using methods in computational toxicology and other recent scientific advances in basic biology. Implementation of the NRC vision will require a major research effort, not unlike that required to successfully map the human genome, extending over 10 to 20 years, involving the broad scientific community to map important toxicity pathways operative in humans. This article provides an overview of the scientific tools and technologies that will form the core of the NRC vision for toxicity testing. Of particular importance will be the development of rapidly performed in vitro screening assays using human cells and cell lines or human tissue surrogates to efficiently identify environmental agents producing critical pathway perturbations. In addition to the overview of the NRC vision, this study documents the reaction by a number of stakeholder groups since 2007, including the scientific, risk assessment, regulatory, and animal welfare communities.
机译：2007年，美国国家研究委员会（NRC）发布了一份报告，“21世纪毒性测试：愿景和战略”，提出了对环境代理人的毒性测试的范式转变。视觉基于暴露于环境代理的观念，通过对人类在人类手术的毒性途径的扰动导致不良健康结果。 NRC Vision的实施将涉及环境因子评估的基本变化，远离实验动物中观察到的不利健康结果，以鉴定毒性途径的关键扰动。将使用体外测定鉴定途径扰动，并在基本生物学中使用方法和其他最近的科学进步，对剂量反应进行定量。 NRC愿景的实施将需要一个重大的研究努力，而不是成功地映射人类基因组，而不是成功地映射10到20年，涉及广泛的科学界，以映射人类的重要毒性途径。本文概述了科学工具和技术，将形成毒性测试NRC视野的核心。特别重要的是使用人体细胞和细胞系或人组织替代品在体外筛选测定中快速进行的发展，以有效地识别产生临时途径扰动的环境试剂。除了NRC愿景的概述外，本研究除自2007年以来，包括一些利益相关者群体的反应，包括科学，风险评估，监管和动物福利社区。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号