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首页> 外文期刊>Journal of Veterinary Research >Roles of African swine fever virus structural proteins in viral infection
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Roles of African swine fever virus structural proteins in viral infection

机译：非洲猪瘟病毒结构蛋白在病毒感染中的作用

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African swine fever virus (ASFV) is a large, double-stranded DNA virus and the sole member of the Asfarviridae family. ASFV infects domestic pigs, wild boars, warthogs, and bush pigs, as well as soft ticks (Ornithodoros erraticus), which likely act as a vector. The major target is swine monocyte-macrophage cells. The virus can cause high fever, haemorrhagic lesions, cyanosis, anorexia, and even fatalities in domestic pigs. Currently, there is no vaccine and effective disease control strategies against its spread are culling infected pigs and maintaining high biosecurity standards. African swine fever (ASF) spread to Europe from Africa in the middle of the 20(th) century, and later also to South America and the Caribbean. Since then, ASF has spread more widely and thus is still a great challenge for swine breeding. The genome of ASFV ranges in length from about 170 to 193 kbp depending on the isolate and contains between 150 and 167 open reading frames (ORFs). The ASFV genome encodes 150 to 200 proteins, around 50 of them structural. The roles of virus structural proteins in viral infection have been described. These proteins, such as pp220, pp62, p72, p54, p30, and CD2v, serve as the major component of virus particles and have roles in attachment, entry, and replication. All studies on ASFV proteins lay a good foundation upon which to clarify the infection mechanism and develop vaccines and diagnosis methods. In this paper, the roles of ASFV structural proteins in viral infection are reviewed.
机译：非洲猪瘟病毒（ASFV）是一种大型双链DNA病毒和Asfarviridae家族的唯一成员。 ASFV感染了家养猪，野猪，疣猪和灌木猪，以及软蜱（Ornithodoros erratictus），这可能是矢量。主要目标是猪单核细胞 - 巨噬细胞细胞。病毒可引起国内猪的高烧，出血性病变，紫绀，厌食，甚至死亡。目前，没有疫苗和有效的疾病控制策略对其涂抹的核糖是剔除感染的猪并保持高生物安全标准。非洲猪瘟（ASF）于20世纪（Th）世纪中叶的非洲蔓延到欧洲，后来也向南美和加勒比地区蔓延到欧洲。从那时起，ASF已经更广泛地传播，因此仍然是猪养殖的巨大挑战。根据隔离物，ASFV的基因组在约170至193kbp的范围内，并且含有150至167个开放阅读框架（ORF）。 ASFV基因组编码150至200蛋白，其中50个结构结构。已经描述了病毒结构蛋白在病毒感染中的作用。这些蛋白质，例如PP220，PP62，P72，P54，P30和CD2V，用作病毒颗粒的主要成分，并且具有附着，入口和复制中的作用。所有关于ASFV蛋白质的研究都奠定了良好的基础，用于阐明感染机制和发育疫苗和诊断方法。本文回顾了ASFV结构蛋白在病毒感染中的作用。

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