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首页> 外文期刊>Journal of Veterinary Research >Withdrawal of amoxicillin and penicillin G procaine from milk after intramammary administration in dairy cows with mastitis
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Withdrawal of amoxicillin and penicillin G procaine from milk after intramammary administration in dairy cows with mastitis

机译：在乳房奶牛内乳腺癌患者乳腺癌后乳汁释放阿莫西林和青霉素G促胰岛素

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Introduction: There are many veterinary products containing beta-lactam antibiotics which are used for mastitis treatment in cows. The aim of the study was to determine whether mastitis could have any effect on amoxicillin (AMX) or penicillin G procaine (PEN) withdrawal period from milk, in the context of current maximum residue limits established by the European Commission. Material and Methods: The study was conducted on 17 dairy Black and White cows with clinical mastitis during the lactation period. The first group (n = 8) received 200 mg of amoxicillin (AMX), whereas the second group (n = 9) received 200,000 IU/mg of penicillin G procaine (PEN) by intramammary administration. For the measurement of AMX and PEN concentrations in milk, the liquid chromatography tandem mass spectrometry method was applied. Pharmacokinetic calculations were performed using Phoenix WinNonlin 6.4 software. Results: The determined AMX and PEN half-life values in the mammary gland suggest that the drug withdrawal is at a level of 99.9% within 81 h (approximate to 3.5 days) and 116 h (approximate to 5 days) after administration of AMX and PEN, respectively. The present research indicates that, at 60 h after administration, the average PEN concentration in the milk from cows with clinical signs of mastitis may still reach 4.96 g/kg and that of AMX can even be 6.92 g/kg. Conclusion: The results obtained confirm that, in mastitis cases, a 72-h withdrawal period is sufficient for elimination of AMX to a lower level than the established maximum residue limit (MRL) values. However, in the case of PEN, at 69 h after administration, the drug concentration may be close to that of the determined MRL.
机译：介绍：含有许多含有β-内酰胺抗生素的兽医产品，用于奶牛中的乳腺炎治疗。该研究的目的是确定乳腺炎是否可以对牛奶的目前的最大残留限制的范围内对牛奶的氨毒素（AMX）或青霉素G Procaine（笔）撤离期有任何影响。材料和方法：在哺乳期间，在17名乳制品黑白奶牛上进行了研究。第一个组（n = 8）接受200mg Amoxicillin（AMX），而第二组（n = 9）通过胎内给药接受200,000个Iu / mg青霉素G丙氨酸（笔）。为了测量牛奶中的AMX和PEN浓度，施加液相色谱串联质谱法。使用Phoenix Winnonlin 6.4软件进行药代动力学计算。结果：乳腺中确定的AMX和PEAL半衰期值表明，在管理AMX的情况下，药物戒断在81小时内（约为3.5天）和116小时（约为5天）的水平为99.9％。笔分别。目前的研究表明，在给药后60小时，患有乳腺炎的奶牛的牛奶的平均笔浓度可能仍然达到4.96克/千克，并且AMX甚至可以为6.92g / kg。结论：得到的结果证实，在乳腺炎病例中，72小时戒断时间足以消除比建立的最大残留量限制（MRL）值较低的含量。然而，在施用后的笔的情况下，在给药后的69小时，药物浓度可以接近确定的MRL。

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