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首页> 外文期刊>Journal of Veterinary Research >Evaluation of susceptibility to antimycobacterial drugs in Mycobacterium tuberculosis complex strains isolated from cattle in Poland
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Evaluation of susceptibility to antimycobacterial drugs in Mycobacterium tuberculosis complex strains isolated from cattle in Poland

机译：从波兰牛分离的分枝杆菌结核复合体菌株中抗菌药物敏感性的评价

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Introduction: Tuberculosis is a highly infectious disease affecting humans and animals. It is caused by the Mycobacterium tuberculosis complex (MTBC) - Mycobacterium bovis and Mycobacterium caprae, which are aetiological factors of bovine tuberculosis (bTB). In Poland, the bTB eradication programme exists. Animals diagnosed with tuberculosis are in the majority of cases not treated, but removed from their herd and then sanitary slaughtered. Material and Methods: In total, 134 MTBC strains isolated from cattle in Poland were subjected to microbiological analysis. The resistance phenotype was tested for first-line antimycobacterial drugs used in tuberculosis treatment in humans: streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. The strains were isolated from tissues collected post mortem, so the test for drug resistance fulfilled only epidemiological criterion. Results: The analysis of drug-resistance of MTBC strains revealed that strains classified as M. bovis were susceptible to 4 antimycobacterial drugs: isoniazid, rifampicin, streptomycin, and ethambutol, and resistant to pyrazynamide. The strains classified as M. caprae were sensitive to all tested drugs. Conclusion: The results indicate that despite enormously dynamic changes in mycobacterial phenotype, Polish strains of MTBC isolated from cattle have not acquired environmental resistance. The strains classified as M. bovis are characterised by natural resistance to pyrazinamide, which is typical for this species.
机译：简介：结核病是一种影响人类和动物的高度传染病。它是由结核分枝杆菌复合体（MTBC） - 牛杆菌和岩孢菌菌的植物杆菌和岩孢菌素引起的，这是牛结核病（BTB）的终止因素。在波兰，存在BTB根除程序。被诊断患有结核病的动物都在大多数情况下未治疗，但从他们的群体中取出然后卫生屠宰。材料和方法：总共，从波兰中分离的134名MTBC菌株进行微生物分析。测试抗性表型对人类结核病治疗中使用的一线抗致剂药物：链霉素，异烟肼，利福平，乙胺醇和吡嗪酰胺。从收集的后验验组织中分离菌株，因此耐药性的试验仅满足流行病学标准。结果：MTBC菌株的耐药性分析显示，群体植物的菌株易于4种抗粘膜药物：异喹啉，利福平，链霉素和乙胺醇，抗眩晕。分类为M. Caprae的菌株对所有测试药物敏感。结论：结果表明，尽管分枝杆菌表型具有极大的动态变化，但从牛中分离的MTBC的波兰菌株均未获得耐燃料。分类为M. Bovis的菌株的特征在于对吡嗪酰胺的耐抗性，这对于该物种是典型的。

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