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首页> 外文期刊>Journal of Veterinary Research >Genetic changes in pigeon paramyxovirus type-1 induced by serial passages in chickens and microscopic lesions caused by the virus in various avian hosts
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Genetic changes in pigeon paramyxovirus type-1 induced by serial passages in chickens and microscopic lesions caused by the virus in various avian hosts

机译：猪野生症病毒型串行通道患者癌症和微观病变诱导的遗传变化，各种禽类主体引起的微观病变

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摘要

Introduction: Genotype VI of avian avulavirus 1 (AAvV-1) has pigeons and doves as its reservoir and is often termed pigeon paramyxovirus type-1 (PPMV-1). The pathogenesis of PPMV-1 infections in poultry is largely obscure. It is known that PPMV-1 requires a series of passages in chickens before it becomes adapted to gallinaceous poultry. Material and Methods: Changes in the genome of PPMV-1 were analysed after serial passages in specific pathogen free (SPF) chickens, using high-throughput sequencing. Additionally, histopathological lesions induced by PPMV-1 in experimentally inoculated pigeons, chickens, and turkeys were evaluated. Results: Following six passages of PPMV-1 in chickens, 10 nonsynonymous substitutions were found including one (in the NP protein) which dominated the genetic pool of viral quasispecies. Histopathological changes induced by the post-passage PPMV-1 strain were more prominent than changes wrought by the pre-passaged PPMV-1 strain and the lesions were most intense in pigeons followed by chickens and turkeys. Conclusion: PPMV-1 is highly adapted to pigeons and passaging through chickens results in the acquisition of novel amino acids in the polymerase complex, which may alter the pathogenic potential of the virus.
机译：简介：禽Avulavirus 1（AAVV-1）的基因型VI有鸽子和鸽子作为其水库，通常被称为鸽子副病毒型-1（PPMV-1）。家禽PPMV-1感染的发病机制在很大程度上是模糊的。众所周知，PPMV-1在适应加油家禽之前需要一系列鸡血管。材料和方法：使用高通量测序在特定病原体（SPF）鸡的串行通道之后分析PPMV-1基因组的变化。另外，评估了通过实验接种鸽子，鸡和火鸡在实验接种鸽子中诱导的组织病理病变。结果：在鸡中六次PPMV-1通道，发现了10个非唯一取代，包括一个（NP蛋白质），其中占据了病毒Quasispecies的遗传池。后通道PPMV-1菌株诱导的组织病理学变化比预先传代的PPMV-1菌株的变化更突出，病变在鸽子中最强烈，其次是鸡和火鸡。结论：PPMV-1高度适应鸽子，通过鸡传代导致聚合酶复合物中的新型氨基酸，这可能改变病毒的病原潜力。

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