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首页> 外文期刊>Journal of Veterinary Research >Simvastatin-induced changes in the leukocytic system of porcine bone marrow
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Simvastatin-induced changes in the leukocytic system of porcine bone marrow

机译：辛伐他汀诱导的猪骨髓白细胞系统的变化

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Introduction: Simvastatin is a substance which is commonly used as a medicine to reduce cholesterol level. Unfortunately, it shows numerous side effects. Simvastatin affects various internal organs, and among other detriments to health may cause persistent muscle weakness, osteolytic processes, headaches, and rashes. Until now knowledge of the influence of simvastatin on bone marrow cells has been rather scant and fragmentary. Material and Methods: During this experiment the numbers of all types of cells in the leukocytic system of porcine bone marrow were evaluated after 28 and 56 days of oral administration of simvastatin at a dose of 40 mg/da/animal. Results: Simvastatin caused an increase in the number of all types of cells in the leukocytic system, and the most visible fluctuations concerned promyelocytes. Conclusion: Observations obtained during the present study indicated that the results of the action of simvastatin on porcine bone marrow differ from those observed in other mammal species, including human. This may be due to various metabolic pathways within the bone marrow in the particular species, but the exact mechanisms of these actions are unknown at the present time.
机译：介绍：辛伐他汀是一种常用作为减少胆固醇水平的药物的物质。不幸的是，它显示了许多副作用。 Simvastatin影响各种内脏，且其他对健康的损害可能导致持续的肌肉弱点，骨​​质溶解过程，头痛和皮疹。到目前为止，现在了解辛伐他汀对骨髓细胞的影响一直是狭窄和零碎的。材料和方法：在此期间，在口服40mg / DA /动物的剂量的辛伐他汀口服施用后，评估猪骨髓的白细胞体系中所有类型细胞的数量。结果：辛伐他汀引起白细胞系统中所有类型细胞数量的增加，以及最明显的波动促幼儿细胞。结论：本研究期间获得的观察结果表明，辛伐他汀对猪骨髓的作用结果与其他哺乳动物物种（包括人）的那些结果不同。这可能是由于特定物种中的骨髓内各种代谢途径，但是目前这些动作的确切机制是未知的。

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