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Evaluation of intestinal damage biomarkers in calves with atresia coli

机译：患有atresia Coli的肠损伤生物标志物的评价

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Introduction: Intestinal obstruction such as atresia coli causes pathophysiological changes in gastrointestinal tissue due to the rise of intra-abdominal pressure. The aim of this study is to determine the intestinal damage with intestinal biomarkers in calves with atresia coli. Material and Methods: The study was conducted on 40 Holstein calves diagnosed with atresia coli with mild to moderate abdominal distention and 10 healthy Holstein calves which served as the control. Blood samples were collected from all calves, and then serum concentrations of intestinal biomarkers were estimated, namely intestinal fatty acid binding protein (IFABP), liver fatty acid binding protein (LFABP), trefoil factor 3 (TFF3), and intestinal alkaline phosphatase (IAP), using commercially available specific bovine ELISA kits. An automatic blood gas analyser was employed for determining the lactate concentration. Results: The concentrations of serum LFABP (P 0.01), IFABP, TFF3, IAP, and blood lactate (P 0.001) were significantly higher in calves with atresia coli than in healthy calves. Conclusion: The calves affected with atresia coli exhibited severe intestinal damage, and IFABP, LFABP, and TFF3 have significant diagnostic importance and play a useful role in determining the intestinal damage due to intestinal obstruction. High levels of IAP and lactate may serve as a signal for the development of intestinal injury.
机译：介绍：肠梗阻等atresia coli由于腹腔内压力升高而导致胃肠组织的病理生理变化。本研究的目的是确定肠道生物标志物的肠损伤与atresia coli。材料和方法：该研究于40只荷斯坦犊牛进行，诊断患有轻度至中度腹胀和10个健康的Holstein小牛，作为对照。从所有犊牛收集血液样品，然后估计肠道生物标志物的血清浓度，即肠脂肪酸结合蛋白（IFAB），肝脂肪酸结合蛋白（LFABP），三叶草因子3（TFF3）和肠碱性磷酸酶（IAP） ），使用市售的特定牛ELISA试剂盒。采用自动血气分析仪来确定乳酸浓度。结果：血清LFABP（P <0.01）的浓度，IFABP，TFF3，IAP和血液乳酸（P <0.001）的牛犊在闭锁性大肠杆菌中显着高于健康的牛犊。结论：对atresia Coli影响的牛犊表现出严重的肠道损伤，IFABP，LFABP和TFF3具有显着的诊断重要性，并在确定由于肠梗阻导致的肠道损伤方面发挥有用作用。高水平的IAP和乳酸可以用作肠损伤的发育的信号。

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