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首页> 外文期刊>American Journal of Microbiology >Prevalence and Antibiotic Sensitivity test of Salmonella Serovars from Enteric Fever Suspected Patients Visiting Alka Hospital, Lalitpur
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Prevalence and Antibiotic Sensitivity test of Salmonella Serovars from Enteric Fever Suspected Patients Visiting Alka Hospital, Lalitpur

机译：来拉利特布尔Alka医院接受肠道热疑似患者的沙门氏菌血清的流行和抗生素敏感性测试

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摘要

Enteric fever is still an important public health problem in developing countries including Nepal. A changing antibiotic susceptibility pattern of Salmonella Typhi and Salmonella Paratyphi A has increased to a great concern. To determine the prevalence and antibiotic sensitivity pattern of S. enteric serovars Typhi and Paratyphi from blood specimen in enteric fever suspected culture positive cases. A cross-sectional study was carried out at Alka hospital, lalitpur. Blood culture samples were collected from suspected enteric fever patient and tested microbiologically by standard procedure. AST was based on Kirby disc diffusion method and results were interpreted according to Clinical Laboratory Standards Institute (CLSI) guidelines. Of total 37 (6.10%) Salmonella serotype isolated from 604 blood culture samples, 25 (67.57%) were S. Typhi and 12 (32.43%) were S. Paratyphi A. Among the culture positive cases, the incidence rate was high in male 70.27% and the age group of 21-30 years showed maximum number of growth i.e., 14 (37.8%). Among the tested antibiotics S. Typhi was fully susceptible towards Ceftriaxone. In case of S. Paratyphi A Ciprofloxacin, Cefriaxone and Cefixime showed 100% susceptibility. Resistant pattern of Salmonella serovars was seen in higher number 34 (91.9%) in the case of Nalidixic acid. Among 37 Salmonella serovars isolated six were found to be Multidrug Resistance (MDR) where four were Salmonella Typhi and two were Salmonella Paratyphi A. Ceftriaxone and Cefixime was the most effective drugs as no isolates were resistant. Ceftriaxone and Cefixime can be the better choice of antibiotic for Salmonella isolates and remains the last drug of choice for S. Typhi and S. Paratyphi A which are also resistant to the first line agents.
机译：在包括尼泊尔在内的发展中国家，肠热仍然是重要的公共卫生问题。伤寒沙门氏菌和副伤寒沙门氏菌A的抗生素易感性模式已引起人们的极大关注。为了确定肠热中怀疑为培养阳性病例的血样中肠炎链球菌伤寒和副伤寒的患病率和抗生素敏感性模式。在拉利特浦的Alka医院进行了横断面研究。从怀疑的肠热患者中收集血液培养物样品，并通过标准程序进行微生物学测试。 AST基于柯比圆盘扩散法，其结果根据临床实验室标准协会（CLSI）指南进行解释。从604份血液培养物中分离出的沙门氏菌血清型共37种（6.10％），其中伤寒沙门氏菌25种（67.57％），副伤寒沙门氏菌12种（32.43％）。在培养阳性病例中，男性的发病率较高。 70.27％和21-30岁的年龄组显示出最大的增长数，即14（37.8％）。在测试的抗生素中，伤寒沙门氏菌对头孢曲松完全敏感。副伤寒沙门氏菌A环丙沙星，头孢曲松和头孢克肟显示为100％敏感性。在萘啶酸的情况下，沙门氏菌血清型的抗药性模式更高，为34（91.9％）。在分离出的37种沙门氏菌血清中，发现有6种具有多重耐药性（MDR），其中有4种是伤寒沙门氏菌，另外2种是副伤寒沙门氏菌。头孢曲松和头孢克肟是最有效的药物，因为没有分离株具有耐药性。头孢曲松和头孢克肟可能是沙门氏菌分离株的更好的抗生素选择，仍然是伤寒沙门氏菌和副伤寒沙门氏菌A的最后选择药物，后者也对一线药物耐药。

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