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首页> 外文期刊>American Journal of Microbiology >Bacteria Contaminants and their Antibiotic Sensitivity from Selected Herbal Medicinal Products from Eldoret and Mombasa, Kenya
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Bacteria Contaminants and their Antibiotic Sensitivity from Selected Herbal Medicinal Products from Eldoret and Mombasa, Kenya

机译：来自肯尼亚埃尔多雷特和蒙巴萨的精选草药产品中的细菌污染物及其抗生素敏感性

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Herbal products are used worldwide for the treatment and prevention of various diseases and currently represent a substantial proportion of the global drug market. However, these products have the potential of being contaminated by different microorganisms due to poor hygienic practices during handling, processing and packaging. The main aim of this study was to evaluate microbial quality of herbal products marketed to the general population in Eldoret and Mombasa, Kenya. The study employed an exploratory as well as laboratory based experimental design. The herbal products were purchased from the markets and transported to Kenya Medical Research Institute laboratories for processing and analysis. Microbial contaminants were determined according to Pharmacopoeias and World Health Organization standards. Microbial pathogens were isolated, identified and drug susceptibility test was done as per National Laboratory Standards Institute protocol. The herbal products were in-form of powders, liquids, tablets, oils and capsules. Bacterial contamination was observed in 90% of the total samples and those with >1000×10~4cfu/gm or ml was 20% for Eldoret and 46% for Mombasa samples. Analysis of variance showed that the rate of microbial contaminants for Eldoret and Mombasa samples had no significant association (p = 0.084). Bacteria belonging to seven genera were isolated and antibiotic susceptibility test showed that 13.2% of the bacteria isolates were resistant. Multidrug resistance was observed with Klebsiella pneumonia, Shigella sonnei, Serratia erwinia, Serratia liquefaciens and Proteus penneri. These findings imply that conditions during harvest or postharvest processing of herbal products were unsanitary. Proper handling and storage of herbs should be observed in order to reduce the amount of microbial contaminants. Only 16% of herbal product samples evaluated met the standards for microbial limits as specified in Pharmacopoeias. Thus, emphasis on improvement of plant material quality and establishing better hygienic conditions during production of herbal medicines is recommended.
机译：草药产品在全球范围内用于治疗和预防各种疾病，目前在全球药品市场中占有相当大的比例。但是，由于在处理，加工和包装过程中的不良卫生习惯，这些产品有可能被不同的微生物污染。这项研究的主要目的是评估向肯尼亚埃尔多雷特和蒙巴萨的普通人群销售的草药产品的微生物质量。该研究采用了探索性的以及基于实验室的实验设计。这些草药产品是从市场上购买的，并运往肯尼亚医学研究所的实验室进行处理和分析。根据药典和世界卫生组织的标准确定微生物污染物。按照国家实验室标准协会的规程分离，鉴定微生物病原体并进行药敏试验。草药产品为粉末，液体，片剂，油和胶囊形式。在所有样本中，有90％观察到细菌污染，而Eldoret样本中> 1000×10〜4cfu / gm或ml的细菌污染为20％，蒙巴萨样本为46％。方差分析表明，埃尔多雷特和蒙巴萨样品的微生物污染物发生率无显着相关性（p = 0.084）。分离出属于七个属的细菌，抗生素敏感性试验表明，分离的细菌中有13.2％具有耐药性。肺炎克雷伯菌，痢疾志贺氏菌，沙雷氏菌欧文氏菌，液化沙雷氏菌和彭氏变形杆菌观察到多药耐药性。这些发现暗示草药产品的收获或收获后加工过程中的条件不卫生。为了减少微生物污染物的数量，应注意正确处理和储存草药。评估的草药产品样本中只有16％符合《药典》中规定的微生物限量标准。因此，建议在草药生产过程中强调改善植物材料的质量并建立更好的卫生条件。

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