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首页> 外文期刊>Journal of trace elements in medicine and biology: Organ of the Society for Minerals and Trace Elements (GMS) >Manganese in blood cells as an exposure biomarker in manganese-exposed workers healthy cohort
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Manganese in blood cells as an exposure biomarker in manganese-exposed workers healthy cohort

机译：血细胞中的锰作为锰暴露工人的曝光生物标志物健康的队列

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摘要

Elevated exposure to manganese (Mn) has long been a public health concern. However, there is currently no consensus on the best exposure biomarker. Here we aimed to investigate the exposomic characteristics of plasma metals among Mn-exposed workers and explore the potential biomarkers of Mn exposure in the blood pool. First, total sixteen plasma metals (Calcium, Magnesium, Iron, Zinc, Copper, Selenium, Lead, Chromium, Arsenic, Manganese, Nickel, Molybdenum, Cadmium, Mercury, Thallium, and Cobalt) were determined among 40 occupationally Mn-exposed subjects. Second, Mn levels in both plasma and blood cells were detected among 234 workers from the manganese-exposed workers healthy cohort (MEWHC), respectively. Analysis of plasma metal exposome showed that the plasma Mn concentrations were positively correlated to plasma Fe (r = 0.361), Ni (r = 0.363), Cr (r = 0.486), and Hg (r = 0.313) (all p 0.05). Mn concentrations in plasma were not significantly correlated to external exposure levels (p(trend) = 0.200), and it was further confirmed among the 234 subjects (p(trend) = 0.452). However, Mn concentrations in blood cells progressively increased as the external exposure dose increased (low-exposure group vs high-exposure group, median 11.53 mu g/L vs 20.41 mu g/L, P-trend = 0.001). Our results suggest that Mn in blood cells, but not plasma, could serve as a potential internal exposure biomarker. Larger validation studies are needed to establish the utility of this biomarker.
机译：锰（MN）的接触升高一直是公共卫生问题。但是，目前在最佳曝光生物标志物上没有共识。在这里，我们旨在调查MN暴露工人之间等离子体金属的强调特征，并探讨血液池中的Mn暴露的潜在生物标志物。首先，在40个职业Mn暴露的受试者中确定了总共16种血浆金属（钙，镁，铁，锌，铜，硒，铅，铬，砷，锰，镍，钼，镉，汞，铊和钴）。其次，分别在234名从锰露的工人健康队列（MEWHC）的234名工人中检测到血浆和血细胞中的MN水平。等离子体金属抑制体的分析表明，等离子体Mn浓度与等离子体Fe（r = 0.361），Ni（r = 0.363），Cr（r = 0.486）和Hg（r = 0.313）呈正相关（所有P <0.05 ）。血浆中的Mn浓度与外部暴露水平没有显着相关（P（趋势）= 0.200），在234个受试者中进一步证实（P（趋势）= 0.452）。然而，随着外部暴露剂量增加（低暴露组VS高曝光组的低暴露组，11.53μg/ L，p趋势= 0.001），血细胞中的Mn浓度逐渐增加。我们的结果表明，血细胞中的MN，但不是血浆，可以用作潜在的内部暴露生物标志物。需要更大的验证研究来建立这种生物标志物的效用。

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    Ge Xiaoting; Wang Fenfen; Zhong Yaoqiu; Lv Yingnan; Jiang Chao; Zhou Yanting; Li Defu; Xia Bing; Su Cheng; Cheng Hong; Ma Yifei; Xiong Feng; Shen Yuefei; Zou Yunfeng; Yang Xiaobo;

  • 作者单位

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Toxicol Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Toxicol Nanning 530021 Peoples R China;

    Guangxi Med Univ Affiliated Hosp 1 Dept Neurol Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Toxicol Nanning 530021 Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Dept Occupat Hlth &

    Environm Hlth Nanning 530021 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Exposome; Manganese; Biomarkers; Plasma; Blood cells;

    机译：exposome;锰;生物标志物;血浆;血细胞;

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