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首页> 外文期刊>American Journal of Perinatology >Stillbirth at term in women of advanced maternal age in the United States: when could the antenatal testing be initiated?
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Stillbirth at term in women of advanced maternal age in the United States: when could the antenatal testing be initiated?

机译：美国高龄产妇在足月胎死腹中：什么时候可以开始产前检查？

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We sought to determine if advanced maternal age (AMA) is a risk factor for intrauterine fetal demise (IUFD). We used a U.S. Centers for Disease Control and Prevention database and analyzed outcomes in women 15 to 44 years of age with term singleton gestations. Cox proportional hazards models and Cochran-Mantel-Haenszel tests were used. Results were controlled for maternal race and smoking. After excluding congenital anomalies and medical complications, 6,239,399 singleton term deliveries were identified. When compared with women 25 to 29 years of age, the risk of IUFD increased with advancing age: 30 to 34 years, odds ratio [OR] = 1.24 (95% confidence interval [CI], 1.13 to 1.36); 35 to 39 years, OR = 1.45 (95% CI, 1.21 to 1.74), and 40 to 44 years, OR = 3.04 (95% CI, 1.58 to 5.86). The risk of IUFD for women 40 to 44 years of age at 39 weeks is comparable with that of 42 weeks in those 25 to 29 years of age. We concluded that AMA is an independent predictor of IUFD, and a strategy of antenatal testingin those > or = 40 years of age beginning at 38 weeks may be considered.
机译：我们试图确定高龄产妇（AMA）是否是子宫内胎儿死亡（IUFD）的危险因素。我们使用了美国疾病预防控制中心数据库，并分析了15至44岁有单胎妊娠的妇女的结局。使用Cox比例风险模型和Cochran-Mantel-Haenszel测试。孕妇种族和吸烟的结果得到控制。在排除先天性异常和医疗并发症之后，确定了6,239,399例单胎分娩。与25至29岁的女性相比，IUFD的风险随着年龄的增长而增加：30至34岁，优势比[OR] = 1.24（95％置信区间[CI]，1.13至1.36）; 35至39年，OR = 1.45（95％CI，1.21至1.74）和40至44年，OR = 3.04（95％CI，1.58至5.86）。 39岁时40至44岁女性的IUFD风险与25岁至29岁女性42周的IUFD风险相当。我们得出的结论是，AMA是IUFD的独立预测因子，可以考虑在38周开始的大于或等于40岁的人群中进行产前检查。

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