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首页> 外文期刊>Journal of women’s health >Pregnant Women Become Sweeter: A Population-Based Study of Trends in Glucose Challenge Test Results Over a Decade
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Pregnant Women Become Sweeter: A Population-Based Study of Trends in Glucose Challenge Test Results Over a Decade

机译：孕妇变得更甜美：一年多次基于人口的血糖挑战测试结果的研究

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Background: Glucose challenge tests (GCTs) are widely used to screen for gestational diabetes mellitus. Women with high normal GCT results may be at increased risk for immediate obstetric complications and future diabetes. We analyzed the similar to 10-year trend in mean GCT results and incidence of high normal (125-140 mg/dL) and abnormal GCT results (>140 mg/dL) in a large cohort of women in Israel. Materials and Methods: Data on all GCTs performed between 2005 and 2016 were gathered from the computerized database of the Central District of Clalit Health Services, the largest Health Maintenance Organization in Israel. Trends over time were studied by time series analysis, and a multivariable logistic model was constructed to study the risk for abnormal results, while adjusting for maternal age and body mass index (BMI). Results: Altogether 101,359 GCTs were analyzed. Over the study period, mean maternal age increased from 28.7 +/- 5.1 to 30.1 +/- 5.1 years and mean GCT results from 101.7 to 114.6 mg/dL (p 140 mg/dL) increased from 10.6% to 18.1% (p 125 mg/dL) from 20.2% to 31.3% (p < 0.001). A multivariable logistic model revealed that later years were associated with an increased risk for abnormal GCT result, while adjusting for maternal age and BMI (adjusted odds ratio = 1.07; 95% confidence interval 1.07-1.08). Conclusions: Over similar to 10 years, mean GCT results and high GCT incidence have significantly increased. These findings are in line with the worldwide diabetes epidemic and demonstrate the worsening in glucose metabolism also in relatively young women.
机译：背景：葡萄糖攻击试验（GCTS）广泛用于筛选妊娠期糖尿病。高正常的GCT结果的女性可能会增加立即产科并发症和未来糖尿病的风险。我们分析了与以色列大型妇女的大型妇女队伍的平均GCT结果和高正常（125-140mg / dl）和异常GCT结果（> 140mg / dl）的发病率类似于10年的趋势。材料和方法：2005年至2016年间的所有GCT的数据来自于以色列最大的健康维护组织的Clalit卫生服务中央区的电脑化数据库。通过时间序列分析研究了随时间的趋势，构建了一种多变量的物流模型，以研究异常结果的风险，同时调整母体年龄和体重指数（BMI）。结果：分析了101,359 GCTS。在研究期间，平均产妇年龄从28.7 +/- 5.1增加到30.1 +/- 5.1岁，平均GCT结果为101.7至114.6 mg / dl（p 140mg / dl）从10.6％增加到18.1％（P 125 Mg / dl）从20.2％〜31.3％（P <0.001）。多变量的逻辑模型显示，后来几年与GCT结果的风险增加有关，同时调整母体年龄和BMI（调整后的差距= 1.07; 95％置信区间1.07-1.08）。结论：超过10年，平均GCT结果和高GCT发病率显着增加。这些发现符合全球糖尿病流行病，并证明葡萄糖代谢的恶化也在相对年轻的女性中。

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