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首页> 外文期刊>Journal of women’s health >Predictive Value of Maternal Serum Biomarkers for Preeclampsia and Birth Weight: A Case-Control Study in Chinese Pregnant Women
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Predictive Value of Maternal Serum Biomarkers for Preeclampsia and Birth Weight: A Case-Control Study in Chinese Pregnant Women

机译：母体血清生物标志物预测价值和出生体重的预测价值 - 中国孕妇案例对照研究

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摘要

Background: In clinical practice, abnormal biochemical changes often occur in women who eventually develop preeclampsia (PE). The study aims to investigate whether maternal serum biochemical markers in the early third trimester can predict PE and neonatal birth weight. Study Design: A retrospective case-control study was performed on 287 women who subsequently developed PE (mild=139; severe=148) and 143 healthy women. Fasting venous blood samples of all gravidas were drawn for routine biochemical markers screening in the early third trimester (28.491.63 weeks). Appropriate statistical methods were selected for analysis with SPSS software. Results: (1) The concentrations of plasma triglyceride (TG), low-density lipoprotein cholesterol (LDL), and uric acid (UA) in the severe and mild subgroups of the PE group were significantly higher compared with the respective levels in the normal pregnancy groups (3.90 vs. 4.03 vs. 3.14mmol/L; 3.41 vs. 3.33 vs. 2.89mmol/L; 365.42 vs. 318.91 vs. 284.69mol/L; p0.0001). Serum calcium levels in PE group were significantly lower than those in control group (2.10 vs. 2.18 vs. 2.22mmol/L; p0.0001). (2) By using the receiver operating characteristic curve to estimate the diagnosis rate of screening for PE of each marker, the highest sensitivity appeared by the combination of TG, total cholesterol (TC), LDL, high-density lipoprotein cholesterol (HDL), LDL/HDL, UA, Ca2+, and homocysteine (HCY) (79%). The area under curve (AUC) of UA was 0.70, which was the highest among these eight markers, but the AUC of an eight-marker combination model (0.85) had a better diagnostic indication. (3) In PE, the maximum systolic/diastolic blood pressure was significantly positively correlated with serum UA (r=0.212/0.205, p0.0001); and negatively correlated with serum total calcium (r=-0.193/-0.196, p=0.001). The neonatal birth weight of PE group had a positive correlation with serum TG levels (r=0.141, p=0.017) and serum total calcium levels (r=0.221, p0.0001), and a negative correlation with UA levels (r=-0.265, p0.0001). Conclusion: The individual marker really performs terrible in predicting PE. Joint monitoring and evaluation of these parameters may improve the screening efficiency for the prediction of PE and poor fetal growth early.
机译：背景：在临床实践中，最终开发出先兆子痫（PE）的女性通常发生异常的生化变化。该研究旨在调查孕产妇血清生物化学标志是否在第三孕孕早期可以预测PE和新生儿出生体重。研究设计：对287名妇女进行了回顾性案例对照研究，随后开发了PE（轻度= 139;严重= 148）和143名健康女性。在第三个妊娠早期（28.491.63周）筛选常规生化标志物的常规生化标志物的禁食静脉血样。选择适当的统计方法进行SPSS软件进行分析。结果：（1）在PE组的严重和温和亚组中，血浆甘油三酯（Tg），低密度脂蛋白胆固醇（LDL）和尿酸（UA）的浓度明显高于正常的相应水平妊娠群（3.90与4.03与3.14mmol / L; 3.41与3.33与2.89mmol / L; 365.42与318.91与284.69mol / L; P <0.0001）。 PE组血清钙水平明显低于对照组（2.10与2.18 Vs.222mol / L; P <0.0001）。 （2）通过使用接收器操作特性曲线来估计每种标记物的PE筛查的诊断率，Tg，总胆固醇（Tc），LDL，高密度脂蛋白胆固醇（HDL）的组合出现的最高敏感性， LDL / HDL，UA，CA2 +和同型半胱氨酸（HCY）（79％）。 UA的曲线（AUC）下的区域为0.70，这是这八个标记中最高的，但八分类组合模型（0.85）的AUC具有更好的诊断迹象。 （3）在PE中，与血清UA（r = 0.212 / 0.205，P <0.0001）显着呈正相关的最大收缩/舒张血压;并与血清总钙（R = -0.193 / -0.196，P = 0.001）负相关。 PE组的新生儿出生体重与血清Tg水平的正相关（r = 0.141，p = 0.017）和血清总钙水平（r = 0.221，p <0.0001），以及与UA水平的负相关（r = - 0.265，P <0.0001）。结论：个人标记真的在预测PE方面表现得很可怕。这些参数的联合监测和评估可以提高PE预测的筛选效率和早期胎儿生长差。

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  • 来源
    《Journal of women’s health》 |2018年第12期|共6页
  • 作者

    Sun Li-Juan; Xu Gu-Feng; Lv Min; Zhou Hao; Huang He-Feng; Luo Qiong;

  • 作者单位

    Zhejiang Univ Womens Hosp Dept Obstet Sch Med 1 Bachelor Rd Hangzhou 310000 Zhejiang Peoples;

    Zhejiang Univ Womens Hosp Dept Obstet Sch Med 1 Bachelor Rd Hangzhou 310000 Zhejiang Peoples;

    Zhejiang Univ Womens Hosp Dept Obstet Sch Med 1 Bachelor Rd Hangzhou 310000 Zhejiang Peoples;

    Zhejiang Univ Womens Hosp Dept Obstet Sch Med 1 Bachelor Rd Hangzhou 310000 Zhejiang Peoples;

    Shanghai Jiao Tong Univ Int Peace Matern &

    Child Hlth Hosp Sch Med Shanghai Peoples R China;

    Zhejiang Univ Womens Hosp Dept Obstet Sch Med 1 Bachelor Rd Hangzhou 310000 Zhejiang Peoples;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇幼卫生;
  • 关键词

    biomarker; birth weight; lipid profile; pregnancy; preeclampsia; predictive value;

    机译：生物标志物;出生体重;脂质剖面;妊娠;预测值;预测值;

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