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首页> 外文期刊>Journal of women’s health >Correlates of Human Papillomavirus Vaccination and Association with HPV-16 and HPV-18 DNA Detection in Young Women
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Correlates of Human Papillomavirus Vaccination and Association with HPV-16 and HPV-18 DNA Detection in Young Women

机译：人乳头瘤病毒疫苗接种和与HPV-16和HPV-18 DNA检测相关联的关联

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Background: Despite a reduction in the prevalence of vaccine-preventable types of human papillomavirus (HPV), attributed to increased HPV vaccine uptake, HPV continues to be a major cause of cancer in the United States. Methods: We assessed factors associated with self-reported HPV vaccine uptake, HPV vaccination effectiveness, using DNA testing to assess HPV types 16 and/or 18 (HPV 16/18) positivity, and patterns of HPV vaccination in 375 women aged 21-29 years who were eligible to receive catch-up vaccination, using baseline data collected from March 2012 to December 2014 from a randomized controlled trial evaluating a novel approach to cervical cancer screening. Results: More than half (n = 228, 60.8%) of participants reported receipt of at least one HPV vaccine dose and 16 (4.3%) tested positive for HPV 16/18 at baseline. College-educated participants were four times more likely to have been vaccinated than those reporting high school education or less. 56.5% of HPV-vaccinated participants reported first dose after age 18 and 68.4% after first vaginal intercourse. Women vaccinated after age 18 and women vaccinated after first vaginal intercourse were somewhat more likely to be infected with HPV 16/18 infection compared with women vaccinated earlier, but these associations did not reach statistical significance. Conclusions: HPV vaccination is common among college-educated women in the catch-up population but less common among those without college education. Contrary to current guidelines, catch-up females frequently obtain HPV vaccination after age 18 and first vaginal intercourse. Women without a college education represent an ideal population for targeted HPV vaccination efforts that emphasize vaccination before sexual debut.
机译：背景：尽管患有疫苗可预防类型的人乳头瘤病毒（HPV）的患病率降低，但由于增加了HPV疫苗摄取，HPV仍然是美国癌症的主要原因。方法：我们评估了与自我报告的HPV疫苗摄取，HPV疫苗接种效果相关的因素，使用DNA检测评估HPV类型16和/或18型（HPV 16/18）积极性，375名275岁女性中的HPV疫苗接种模式有资格获得追赶疫苗接种的岁月，从2012年3月至2014年12月收集的基线数据，从一项随机对照试验评估了一种新的宫颈癌筛查方法。结果：超过一半（n = 228,60.8％）参与者报告收到至少一种HPV疫苗剂量和16（4.3％）在基线下测试HPV 16/18的阳性。教育参与者比报告高中教育或更少的人接种了四倍。 56.5％的HPV接种疫苗的参与者在第一次阴道性交后18岁和68.4％后报告了第一剂量。妇女接种18岁以后，与早期接种的女性相比，第一次阴道性交接种的妇女疫苗有点可能感染HPV 16/18感染，但这些协会没有达到统计学意义。结论：HPV疫苗接种在追赶人口中的大学教育女性中常见，但在没有大学教育的人群中不那么常见。与目前的准则相反，追赶女性经常在18岁后获得HPV疫苗接种，第一次阴道性交。没有大学教育的妇女代表了针对性HPV疫苗接种努力的理想人群，在性亮相之前强调疫苗接种。

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