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首页> 外文期刊>Journal of women’s health >The Impact of Antithrombin Deficiency on Women's Reproductive Health Experiences and Healthcare Decision-Making
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The Impact of Antithrombin Deficiency on Women's Reproductive Health Experiences and Healthcare Decision-Making

机译：抗凝血酶缺乏对妇女生殖健康经验和医疗决策的影响

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Background: Women with inherited antithrombin (AT) deficiency are at high risk for venous thromboembolism (VTE), especially during times of estrogen exposure, but little is known about patient-oriented reproductive decision-making in this population. Materials and Methods: Provider-administered survey of women with AT deficiency. Participants were asked to discuss their diagnosis of AT deficiency and questioned about (1) contraception, (2) pregnancies, and (3) menorrhagia, and the impact of their AT deficiency on each reproductive health experience. Results: Of 31 women with inherited AT deficiency, 18 (58%) were surveyed, 8 (26%) were unreachable, and 5 (16%) were deceased. Twelve (67%) had a VTE, including two which occurred during pregnancy and five during oral contraceptive (OCP) use. Women reported using OCPs, intrauterine device (IUD), and condoms for contraception. Of five women diagnosed with AT deficiency while taking OCPs, three switched to an IUD, one to condoms, and one used no alternative method. Eighteen women reported 42 total pregnancies, with 33 (79%) resulting in live term birth, 3 (7%) in live preterm birth, and 6 (14%) in spontaneous abortion at a median of 12 weeks. Four (22%) women reported the use of anticoagulation during pregnancy. Eleven (61%) women reported menorrhagia and 4 (36%), while on anticoagulation for VTE events. Ten of 18 women (56%) reported that the diagnosis of AT had affected their reproductive health in some way. Conclusion: Women with AT deficiency require careful multidisciplinary management to avoid complications in the setting of contraception and pregnancy. AT deficiency impacts women's reproductive health experiences and patient-oriented reproductive decision-making is key.
机译：背景：患有抗抗凝血酶（AT）缺陷的妇女对静脉血栓栓塞（VTE）的风险很高，特别是在雌激素暴露期间，但对该人群的患者导向的生殖决策很少。材料与方法：提供缺乏症的妇女的提供者调查。要求参与者讨论其对缺乏的诊断，并质疑（1）避孕，（2）怀孕，（3）美甲，以及他们对每种生殖健康经验的缺陷的影响。结果：调查了31名患有缺乏的女性，18例（58％）进行了调查，8（26％）无法访问，5名（16％）已故死亡。十二（67％）具有VTE，包括怀孕期间发生的两种，并且在口服避孕药中发生（OCP）使用。妇女报告使用OCP，宫内设备（IUD）和避孕套进行避孕。在服用缺陷时诊断患有缺陷的五个女性，三个转换为一个到避孕套，一个人没有使用替代方法。十八名女性报告了42例妊娠，33（79％）导致生命早产的出生，3（7％）出生，6（14％）在12周的中位数的自发流产。四（22％）妇女报告在怀孕期间使用抗凝。 11（61％）女性报告了Metorragia和4（36％），同时对VTE事件的抗凝。 18名女性中有10名（56％）报道称，诊断在某种程度上影响了他们的生殖健康。结论：缺陷的妇女需要仔细的多学科管理，以避免在避孕和怀孕的环境中的并发症。在缺陷会影响女性的生殖健康经验和以患者为导向的生殖决策是关键。

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