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首页> 外文期刊>Journal of women’s health >A Randomized Controlled Multicenter Trial of an Investigational Liquid Nutritional Formula in Women with Cyclic Breast Pain Associated with Fibrocystic Breast Changes
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A Randomized Controlled Multicenter Trial of an Investigational Liquid Nutritional Formula in Women with Cyclic Breast Pain Associated with Fibrocystic Breast Changes

机译：患有纤维囊乳腺乳腺乳腺疼痛的妇女调查液体营养公式的随机对照多中心试验

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Objective: A randomized, multicenter, controlled double-blind trial was performed in women with cyclic breast pain (mastalgia) associated with fibrocystic breast changes (FBCs) to determine whether a nutritional formula reduced breast pain and/or nodularity. Study Design: Women were randomized to receive a specifically designed liquid formulation ( n = 93) (1 g gamma-linolenic acid [GLA], 750 μg iodine, and 70 μg selenium) or control formula ( n = 95) (without GLA, iodine, and selenium) daily for three cycles. Women recorded breast pain, medications, and menstrual signs daily using interactive voice-response system. Nodularity was determined by physical breast examination. Results: Breast pain scores decreased similarly in the experimental (?32.2%) and control (?33.1%) groups ( p = 0.64). Nodularity was reduced in the experimental, but not the control group ( p = 0.03). Among women who continued pain medication, the amount was reduced in the experimental group relative to controls ( p = 0.02). Conclusion: Women with FBC using the formula containing GLA, iodine, and selenium experienced reduced nodularity and in those women who took over-the-counter breast pain medication, a decrease in the quantity of pain medication was observed.
机译：目的：随机，多中心受控的双盲试验在患有纤维胸腺乳腺疼痛（FBCS）相关的循环乳腺疼痛（Mastalgia）中进行，以确定营养配方是否降低乳房疼痛和/或结节性。研究设计：妇女随机接受专门设计的液体制剂（n = 93）（1gγ-亚麻酸湿[gla]，750μg碘和70μg硒）或对照式（n = 95）（没有gla，碘和硒）每天为三个周期。使用交互式语音响应系统每天记录乳房疼痛，药物和月经迹象。通过物理乳房检查确定结节性。结果：实验（β32.2％）和对照（α33.1％）组（P = 0.64），乳房疼痛评分同样下降。实验中的结节性降低，但不是对照组（P = 0.03）。在持续止痛药的妇女中，实验组相对于对照组中的量减少了（P = 0.02）。结论：FBC使用含有GLA，碘和硒的配方的妇女经历了降低的结节性，并且在那些接管乳房疼痛药物的女性中，观察到止痛药量的降低。

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