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首页> 外文期刊>Journal of women’s health >Characterization and Treatment of Recurrent Bacterial Vaginosis
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Characterization and Treatment of Recurrent Bacterial Vaginosis

机译：复发性细菌性阴道病的特征和治疗

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Bacterial vaginosis (BV) is a common but treatable condition, with a number of effective available treatments, including oral and intravaginal metronidazole and clindamycin and oral tinidazole. However, as many as 50% of women with BV experience recurrence within 1 year of treatment for incident disease. Some reasons for recurrence include the persistence of residual infection, resistance, and possibly reinfection from either male or female partners. Persistence may occur due to the formation of a biofilm that protects BV-causing bacteria from antimicrobial therapy. Poor adherence to treatment among patients with genitourinary infections may lead to resistance. However, the underlying mechanisms of recurrent etiology of BV are not known. Recommended treatment for recurrent BV consists of an extended course of metronidazole treatment (500 mg twice daily for 10-14 days); if ineffective, metronidazole vaginal gel 0.75% for 10 days, followed by two times per week for 3-6 months, is an alternate treatment regimen. Past studies of clindamycin and tinidazole in the treatment of recurrent BV have focused on patients with evidence of metronidazole resistance. Secnidazole may be an attractive new option due to one-time dosing. Initial studies on biofilm disruption, use of probiotics and prebiotics, and botanical treatments have shown some promise, but must be studied further before use in the clinic. Despite limitations, antimicrobial therapy will remain the mainstay of treatment for recurrent BV for the foreseeable future.
机译：细菌性阴道病（BV）是一种常见但可治疗的病症，具有许多有效的可用处理，包括口服和静脉内甲唑和克林霉素和口服锡咪唑。但是，在入射疾病的治疗后的1年内，多达50％的女性患有BV体验复发。复发的一些原因包括残留感染，抗性和可能从男性或女性合作伙伴中重新感染的持续性。由于生物膜形成，可能发生持久性，这些生物膜可保护BV导致细菌免受抗微生物治疗。对泌尿病感染患者的治疗粘附不良可能导致抗性。然而，BV的复发性病因的潜在机制尚不清楚。用于复发性BV的推荐治疗包括矿氮唑处理的扩展过程（每日两次为500毫克10-14天）;如果无效，甲硝唑阴道凝胶0.75％10天，其次每周两次3-6个月，是替代治疗方案。过去研究克林霉素和锡咪唑治疗复发性BV的患者集中于患有甲硝唑抗性的患者。由于一次性给药，Secnidazole可能是一种有吸引力的新选择。初步研究生物膜破坏，益生菌和益生元和植物治疗的使用表现出了一些承诺，但必须在诊所使用前进一步研究。尽管有局限性，但抗菌治疗将仍将是可预见的未来复发性BV的疗法的主要支柱。

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