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首页> 外文期刊>Journal of women’s health >Sex Differences in Traditional and Nontraditional Risk Factors for Obstructive Coronary Artery Disease in Stable Symptomatic Patients
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Sex Differences in Traditional and Nontraditional Risk Factors for Obstructive Coronary Artery Disease in Stable Symptomatic Patients

机译：稳定症状患者阻塞性冠状动脉疾病的传统和非传统风险因素的性差异

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Background: There have been limited data on sex-specific risk factors for coronary artery disease (CAD) in patients with stable chest pain. This study was performed to investigate whether risk factors for CAD differ by sex in stable symptomatic patients. Methods: Data were obtained from a nation-wide registry, enrolling 1025 patients (age, 62.0 ± 11.0 years, 587 women) with chest pain who underwent elective invasive coronary angiography under the suspicion of CAD. Results: A total of 373 patients (36.4%) had obstructive CAD (≥50% stenosis) (men vs. women: 33.8% vs. 38.3%, p = 0.135). In men, univariate analyses showed that age, renal function, total cholesterol, low-density lipoprotein cholesterol, triglyceride, C-reactive protein (CRP), left ventricular (LV) systolic function, and septal annular velocity of LV (e′) were significantly associated with the presence of obstructive CAD. Among these factors, a high CRP level (≥0.50 mg/dL) was an independent predictor of CAD in multivariable analysis (odds ratio [OR], 2.93; 95% confidence interval [CI], 1.26–6.82; p = 0.012). In women, univariate analyses showed that age, waist circumference, heart rate, hypertension, diabetes mellitus, low high-density lipoprotein cholesterol, LV systolic function, LV mass index, e′ velocity, E/e′, and left atrial size were significantly associated with the presence of obstructive CAD. Among these factors, lower e′ velocity ( p = 0.012). Conclusions: Among patients with stable chest pain, inflammation and LV diastolic dysfunction are independently associated with obstructive CAD in men and women, respectively.
机译：背景：胸部疼痛患者冠状动脉疾病（CAD）的性别特异性风险因素有限。进行该研究进行调查是否在稳定的症状患者中对CAD的风险因素不同。方法：从全国范围的注册表中获得数据，注册1025名患者（年龄，62.0±11.0岁，587名女性），胸部疼痛在怀疑CAD下接受选修冠状动脉造影。结果：共有373名患者（36.4％）具有阻塞性的CAD（≥50％的狭窄）（男性与女性：33.8％vs.38.3％，P = 0.135）。在男性中，单变量分析表明，年龄，肾功能，总胆固醇，低密度脂蛋白胆固醇，甘油三酯，C反应蛋白（CRP），左心室（LV）收缩函数和LV（E'）的隔膜环形速度是显着与阻塞性CAD的存在有关。在这些因素中，高CRP水平（≥0.50mg/ dl）是多变量分析中CAD的独立预测因子（差距比[或]，2.93; 95％置信区间[CI]，1.26-6.82; P = 0.012）。在女性中，单变量分析表明，年龄，腰围，心率，高血压，糖尿病，低密度脂蛋白胆固醇，LV收缩功能，LV质量指数，E'速度，E / E'和左心房尺寸与阻塞性CAD的存在相关联。在这些因素中，较低的E'速度（p = 0.012）。结论：胸痛稳定的患者，炎症和LV舒张功能障碍分别与男性和女性的阻塞性CAD独立相关。

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