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首页> 外文期刊>Journal of women’s health >Association Between Migraine and Breast Cancer Risk: A Population-Based Cohort Study and Literature Review
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Association Between Migraine and Breast Cancer Risk: A Population-Based Cohort Study and Literature Review

机译：偏头痛与乳腺癌风险之间的关联：基于人口的队列研究与文献综述

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Objective: Previous case-control studies have suggested that women with migraine have lower risk of developing breast cancer, but conflicting results were noted in cohort studies. We investigated the association between migraine and breast cancer incidence in a nationwide population-based cohort study. Methods: We identified 25,606 women with migraine between 2000 and 2013 from the National Health Insurance Research Database in Taiwan. Each migraineur was randomly frequency matched with four women without migraine by age and index year of migraine diagnosis. Cox's proportional hazard regression analysis was performed to estimate the association between migraine on the risk of developing breast cancer. Results: With a mean follow-up of 7.3 years, 234 and 978 breast malignancies occurred in the migraine cohort and matched cohort, respectively. Migraine was not associated with the risk of breast cancer (adjusted hazard ratio = 1.03, 95% confidence interval = 0.89-1.21). Among women with migraine, independent risk factors for breast cancer included older age, alcohol-related illness, and receipt of a greater number of breast cancer screening examinations, and independent protective factors included the use of antihypertensive agents, statins, and nonsteroidal anti-inflammatory drugs. Further analyses indicated that women with = 4 medical visits for migraine per year had a significantly greater risk of breast cancer than the matched cohort. Conclusions: Migraine was not associated with a decreased risk of developing breast cancer among Taiwanese women. Further prospective studies on other geographic populations or on the association between migraine frequency and the risk of developing breast cancer are warranted to validate our findings.
机译：目的：以前的病例对照研究表明，患有偏头痛的女性患有患乳腺癌的风险较低，但在队列研究中指出了相互矛盾的结果。我们调查了全国基于人群的群组研究中偏头痛和乳腺癌发病率之间的关联。方法：从台湾国家医疗保险研究数据库中确定了25,606名2000年至2013年偏头痛。每个偏头痛随机频率与四个女性匹配，没有偏头痛的偏头痛诊断。 COX的比例危害回归分析进行了估算偏头痛与发育乳腺癌风险的关系。结果：平均随访7.3岁，分别发生在偏头痛队列和匹配的队列中发生的234岁和978例乳腺恶性肿瘤。偏头痛与乳腺癌的风险无关（调节危险比= 1.03,95％置信区间= 0.89-1.21）。在患有偏头痛的妇女中，乳腺癌的独立危险因素包括较老年，酒精相关的疾病，以及接收更多乳腺癌筛查检查，以及独立的保护因素包​​括使用抗高血压药物，他汀类药物和非甾体抗炎剂药物。进一步的分析表明，妇女患有＆ = 4每年的偏头痛的医疗访问乳腺癌的风险明显更大，而不是匹配的队列。结论：偏头痛与台湾女性中乳腺癌的风险降低无关。有关其他地理种群或偏头痛频率与发育乳腺癌风险之间的进一步前瞻性研究是值得验证我们的研究结果。

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